Fluorescence enhancement of N 2O 2-type dipyrrin ligand in two step responding to zinc(II) ion

Hyesun Song; Senkuttuvan Rajendiran; Eunhae Koo; Byoung Koun Min; Soon Kwan Jeong; T. Daniel Thangadurai; Sungho Yoon

doi:10.1016/j.jlumin.2012.06.024

Fluorescence enhancement of N ₂O ₂-type dipyrrin ligand in two step responding to zinc(II) ion

Hyesun Song, Senkuttuvan Rajendiran, Eunhae Koo, Byoung Koun Min, Soon Kwan Jeong, T. Daniel Thangadurai, Sungho Yoon

GREEN SCHOOL (Graduate School of Energy and Environment)

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Fluorescence imaging is well-suited for the live imaging of biological Zn(II), which has no facile spectroscopic or magnetic signature. The successful application of this methodology requires the development of robust Zn(II) imaging agents that display high sensitivity, selectivity and temporal fidelity. In this study, a N ₂O ₂-type dipyrrin based bimolecular zinc(II) complex was produced and shown to have sharper, blue-shifted and more enhanced fluorescence emission. An approximate three-fold fluorescence enhancement was achieved within the micromolar concentration range, which is an important parameter for Zn(II) detection in vivo. The increase in emission intensity was due to the dominant role of aryl-ring rotation in governing the excited state dynamics and fluorescence properties of the dipyrrin dye. Fluorescence titration showed that the ligand complex exhibited very strong zinc(II) binding affinity when compared to that in the binuclear chloro complex. The fluorescence emission changes in the dipyrrin dye to zinc(II) ion could be observed not only using instruments but also by the naked-eye (violet→sky blue).

Original language	English
Pages (from-to)	3089-3092
Number of pages	4
Journal	Journal of Luminescence
Volume	132
Issue number	11
DOIs	https://doi.org/10.1016/j.jlumin.2012.06.024
Publication status	Published - 2012 Nov

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) ( KRF-2008-C00146 ), by the Industrial Technology Development Program funded by the Ministry of Knowledge Economy (MKE, Korea), and also by a grant from the Fundamental R&D program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea.

Keywords

Detection limit
Dipyrrin
Fluorescence enhancement
Ligand complex
Zinc(II)

ASJC Scopus subject areas

Biophysics
Biochemistry
General Chemistry
Atomic and Molecular Physics, and Optics
Condensed Matter Physics

Access to Document

10.1016/j.jlumin.2012.06.024

Cite this

@article{1a07a17f17934b92a50e96c8a9030839,

title = "Fluorescence enhancement of N 2O 2-type dipyrrin ligand in two step responding to zinc(II) ion",

abstract = "Fluorescence imaging is well-suited for the live imaging of biological Zn(II), which has no facile spectroscopic or magnetic signature. The successful application of this methodology requires the development of robust Zn(II) imaging agents that display high sensitivity, selectivity and temporal fidelity. In this study, a N 2O 2-type dipyrrin based bimolecular zinc(II) complex was produced and shown to have sharper, blue-shifted and more enhanced fluorescence emission. An approximate three-fold fluorescence enhancement was achieved within the micromolar concentration range, which is an important parameter for Zn(II) detection in vivo. The increase in emission intensity was due to the dominant role of aryl-ring rotation in governing the excited state dynamics and fluorescence properties of the dipyrrin dye. Fluorescence titration showed that the ligand complex exhibited very strong zinc(II) binding affinity when compared to that in the binuclear chloro complex. The fluorescence emission changes in the dipyrrin dye to zinc(II) ion could be observed not only using instruments but also by the naked-eye (violet→sky blue).",

keywords = "Detection limit, Dipyrrin, Fluorescence enhancement, Ligand complex, Zinc(II)",

author = "Hyesun Song and Senkuttuvan Rajendiran and Eunhae Koo and Min, {Byoung Koun} and Jeong, {Soon Kwan} and {Daniel Thangadurai}, T. and Sungho Yoon",

note = "Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) ( KRF-2008-C00146 ), by the Industrial Technology Development Program funded by the Ministry of Knowledge Economy (MKE, Korea), and also by a grant from the Fundamental R&D program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea. ",

year = "2012",

month = nov,

doi = "10.1016/j.jlumin.2012.06.024",

language = "English",

volume = "132",

pages = "3089--3092",

journal = "Journal of Luminescence",

issn = "0022-2313",

publisher = "Elsevier",

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T1 - Fluorescence enhancement of N 2O 2-type dipyrrin ligand in two step responding to zinc(II) ion

AU - Song, Hyesun

AU - Rajendiran, Senkuttuvan

AU - Koo, Eunhae

AU - Min, Byoung Koun

AU - Jeong, Soon Kwan

AU - Daniel Thangadurai, T.

AU - Yoon, Sungho

N1 - Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) ( KRF-2008-C00146 ), by the Industrial Technology Development Program funded by the Ministry of Knowledge Economy (MKE, Korea), and also by a grant from the Fundamental R&D program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea.

PY - 2012/11

Y1 - 2012/11

N2 - Fluorescence imaging is well-suited for the live imaging of biological Zn(II), which has no facile spectroscopic or magnetic signature. The successful application of this methodology requires the development of robust Zn(II) imaging agents that display high sensitivity, selectivity and temporal fidelity. In this study, a N 2O 2-type dipyrrin based bimolecular zinc(II) complex was produced and shown to have sharper, blue-shifted and more enhanced fluorescence emission. An approximate three-fold fluorescence enhancement was achieved within the micromolar concentration range, which is an important parameter for Zn(II) detection in vivo. The increase in emission intensity was due to the dominant role of aryl-ring rotation in governing the excited state dynamics and fluorescence properties of the dipyrrin dye. Fluorescence titration showed that the ligand complex exhibited very strong zinc(II) binding affinity when compared to that in the binuclear chloro complex. The fluorescence emission changes in the dipyrrin dye to zinc(II) ion could be observed not only using instruments but also by the naked-eye (violet→sky blue).

AB - Fluorescence imaging is well-suited for the live imaging of biological Zn(II), which has no facile spectroscopic or magnetic signature. The successful application of this methodology requires the development of robust Zn(II) imaging agents that display high sensitivity, selectivity and temporal fidelity. In this study, a N 2O 2-type dipyrrin based bimolecular zinc(II) complex was produced and shown to have sharper, blue-shifted and more enhanced fluorescence emission. An approximate three-fold fluorescence enhancement was achieved within the micromolar concentration range, which is an important parameter for Zn(II) detection in vivo. The increase in emission intensity was due to the dominant role of aryl-ring rotation in governing the excited state dynamics and fluorescence properties of the dipyrrin dye. Fluorescence titration showed that the ligand complex exhibited very strong zinc(II) binding affinity when compared to that in the binuclear chloro complex. The fluorescence emission changes in the dipyrrin dye to zinc(II) ion could be observed not only using instruments but also by the naked-eye (violet→sky blue).

KW - Detection limit

KW - Dipyrrin

KW - Fluorescence enhancement

KW - Ligand complex

KW - Zinc(II)

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