Fluorescence imaging of pathophysiological microenvironments

Shan Wang, Wen Xiu Ren, Ji Ting Hou, Miae Won, Jusung An, Xiaoyuan Chen, Jian Shu, Jong Seung Kim

Research output: Contribution to journalReview articlepeer-review

253 Citations (Scopus)


Abnormal microenvironments (viscosity, polarity, pH, etc.) have been verified to be closely associated with numerous pathophysiological processes such as inflammation, neurodegenerative diseases, and cancer. As a result, deep insights into these pathophysiological microenvironments are particularly beneficial for clinical diagnosis and treatment. However, the monitoring of pathophysiological microenvironments is unattainable by the traditional clinical diagnostic techniques such as magnetic resonance imaging, computed tomography, and positron emission tomography. Recently, fluorescence imaging has shown tremendous advantages and potential in the tracing of pathophysiological microenvironment variations. In this context, a general discussion is provided on the state-of-the-art progress of fluorescent probes for visualizing pathophysiological microenvironments (viscosity, pH, and polarity), since 2016, as well as the future perspectives in this challenging field.

Original languageEnglish
Pages (from-to)8887-8902
Number of pages16
JournalChemical Society Reviews
Issue number16
Publication statusPublished - 2021 Aug 21

Bibliographical note

Funding Information:
This work was financially supported by the National Natural Science Foundation of China (no. 21807029), the Nanhu Scholars Program for Young Scholars of XYNU, Chunhui Project of the Ministry of Education of China, the National University of Singapore Start-up Grant (NUHSRO/2020/133/Startup/08), and the NUS School of Medicine Nanomedicine Translational Research Programme (NUHSRO/2021/034/TRP/09/Nanomedi-cine). Also, this work was supported by the National Research Foundation of Korea (C. R. I. project no. 2018R1A3B1052702 and NRF-2019M3E5D1A01068998, J. S. K.) and the Basic Science Research Program (2020R1A6A3A01100551, M. W.).

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus subject areas

  • General Chemistry


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