TY - JOUR
T1 - Fluorescence imaging of pathophysiological microenvironments
AU - Wang, Shan
AU - Ren, Wen Xiu
AU - Hou, Ji Ting
AU - Won, Miae
AU - An, Jusung
AU - Chen, Xiaoyuan
AU - Shu, Jian
AU - Kim, Jong Seung
N1 - Funding Information:
This work was financially supported by the National Natural Science Foundation of China (no. 21807029), the Nanhu Scholars Program for Young Scholars of XYNU, Chunhui Project of the Ministry of Education of China, the National University of Singapore Start-up Grant (NUHSRO/2020/133/Startup/08), and the NUS School of Medicine Nanomedicine Translational Research Programme (NUHSRO/2021/034/TRP/09/Nanomedi-cine). Also, this work was supported by the National Research Foundation of Korea (C. R. I. project no. 2018R1A3B1052702 and NRF-2019M3E5D1A01068998, J. S. K.) and the Basic Science Research Program (2020R1A6A3A01100551, M. W.).
Publisher Copyright:
© The Royal Society of Chemistry.
PY - 2021/8/21
Y1 - 2021/8/21
N2 - Abnormal microenvironments (viscosity, polarity, pH, etc.) have been verified to be closely associated with numerous pathophysiological processes such as inflammation, neurodegenerative diseases, and cancer. As a result, deep insights into these pathophysiological microenvironments are particularly beneficial for clinical diagnosis and treatment. However, the monitoring of pathophysiological microenvironments is unattainable by the traditional clinical diagnostic techniques such as magnetic resonance imaging, computed tomography, and positron emission tomography. Recently, fluorescence imaging has shown tremendous advantages and potential in the tracing of pathophysiological microenvironment variations. In this context, a general discussion is provided on the state-of-the-art progress of fluorescent probes for visualizing pathophysiological microenvironments (viscosity, pH, and polarity), since 2016, as well as the future perspectives in this challenging field.
AB - Abnormal microenvironments (viscosity, polarity, pH, etc.) have been verified to be closely associated with numerous pathophysiological processes such as inflammation, neurodegenerative diseases, and cancer. As a result, deep insights into these pathophysiological microenvironments are particularly beneficial for clinical diagnosis and treatment. However, the monitoring of pathophysiological microenvironments is unattainable by the traditional clinical diagnostic techniques such as magnetic resonance imaging, computed tomography, and positron emission tomography. Recently, fluorescence imaging has shown tremendous advantages and potential in the tracing of pathophysiological microenvironment variations. In this context, a general discussion is provided on the state-of-the-art progress of fluorescent probes for visualizing pathophysiological microenvironments (viscosity, pH, and polarity), since 2016, as well as the future perspectives in this challenging field.
UR - http://www.scopus.com/inward/record.url?scp=85113906673&partnerID=8YFLogxK
U2 - 10.1039/d1cs00083g
DO - 10.1039/d1cs00083g
M3 - Review article
C2 - 34195735
AN - SCOPUS:85113906673
SN - 0306-0012
VL - 50
SP - 8887
EP - 8902
JO - Chemical Society Reviews
JF - Chemical Society Reviews
IS - 16
ER -
