Fluorescent coumarinyldithiane as a selective chemodosimeter for mercury(II) ion in aqueous solution

Ja Hyung Kim; Hyun Jung Kim; Sang Hoon Kim; Jae Hong Lee; Jung Ho Do; Hae Jo Kim; Joung Hae Lee; Jong Seung Kim

doi:10.1016/j.tetlet.2009.08.045

Fluorescent coumarinyldithiane as a selective chemodosimeter for mercury(II) ion in aqueous solution

Ja Hyung Kim, Hyun Jung Kim, Sang Hoon Kim, Jae Hong Lee, Jung Ho Do, Hae Jo Kim, Joung Hae Lee, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Abstract

A coumarin-based dithiane (1) was synthesized for the selective detection of Hg²⁺ with respect to dual chromo- and fluorogenic changing events in an aqueous solution by the mercury-promoted transformation of a dithiane group into an aldehyde functional unit. The Hg²⁺-selective response of the chemodosimeter was clearly observed in aqueous buffer as well as in human blood plasma medium.

Original language	English
Pages (from-to)	5958-5961
Number of pages	4
Journal	Tetrahedron Letters
Volume	50
Issue number	43
DOIs	https://doi.org/10.1016/j.tetlet.2009.08.045
Publication status	Published - 2009 Oct 28

Keywords

Chromogenic
Coumarin
Fluorogenic
Mercury ion

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2009.08.045

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title = "Fluorescent coumarinyldithiane as a selective chemodosimeter for mercury(II) ion in aqueous solution",

abstract = "A coumarin-based dithiane (1) was synthesized for the selective detection of Hg2+ with respect to dual chromo- and fluorogenic changing events in an aqueous solution by the mercury-promoted transformation of a dithiane group into an aldehyde functional unit. The Hg2+-selective response of the chemodosimeter was clearly observed in aqueous buffer as well as in human blood plasma medium.",

keywords = "Chromogenic, Coumarin, Fluorogenic, Mercury ion",

author = "Kim, {Ja Hyung} and Kim, {Hyun Jung} and Kim, {Sang Hoon} and Lee, {Jae Hong} and Do, {Jung Ho} and Kim, {Hae Jo} and Lee, {Joung Hae} and Kim, {Jong Seung}",

note = "Funding Information: This work was supported by the Creative Research Initiative Program of the MEST, SRC (No. R11-2005-008-00000-0 ) and KRF ( KRF-2008-313-C00501 and KRF-2008-313-C00508 ). ",

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doi = "10.1016/j.tetlet.2009.08.045",

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journal = "Tetrahedron Letters",

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T1 - Fluorescent coumarinyldithiane as a selective chemodosimeter for mercury(II) ion in aqueous solution

AU - Kim, Ja Hyung

AU - Kim, Hyun Jung

AU - Kim, Sang Hoon

AU - Lee, Jae Hong

AU - Do, Jung Ho

AU - Kim, Hae Jo

AU - Lee, Joung Hae

AU - Kim, Jong Seung

N1 - Funding Information: This work was supported by the Creative Research Initiative Program of the MEST, SRC (No. R11-2005-008-00000-0 ) and KRF ( KRF-2008-313-C00501 and KRF-2008-313-C00508 ).

PY - 2009/10/28

Y1 - 2009/10/28

N2 - A coumarin-based dithiane (1) was synthesized for the selective detection of Hg2+ with respect to dual chromo- and fluorogenic changing events in an aqueous solution by the mercury-promoted transformation of a dithiane group into an aldehyde functional unit. The Hg2+-selective response of the chemodosimeter was clearly observed in aqueous buffer as well as in human blood plasma medium.

AB - A coumarin-based dithiane (1) was synthesized for the selective detection of Hg2+ with respect to dual chromo- and fluorogenic changing events in an aqueous solution by the mercury-promoted transformation of a dithiane group into an aldehyde functional unit. The Hg2+-selective response of the chemodosimeter was clearly observed in aqueous buffer as well as in human blood plasma medium.

KW - Chromogenic

KW - Coumarin

KW - Fluorogenic

KW - Mercury ion

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M3 - Article

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SN - 0040-4039

VL - 50

SP - 5958

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 43

ER -

Fluorescent coumarinyldithiane as a selective chemodosimeter for mercury(II) ion in aqueous solution

Abstract

Keywords

ASJC Scopus subject areas

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