Fluorescent coumarinyldithiane as a selective chemodosimeter for mercury(II) ion in aqueous solution

Ja Hyung Kim, Hyun Jung Kim, Sang Hoon Kim, Jae Hong Lee, Jung Ho Do, Hae Jo Kim, Joung Hae Lee, Jong Seung Kim

    Research output: Contribution to journalArticlepeer-review

    89 Citations (Scopus)

    Abstract

    A coumarin-based dithiane (1) was synthesized for the selective detection of Hg2+ with respect to dual chromo- and fluorogenic changing events in an aqueous solution by the mercury-promoted transformation of a dithiane group into an aldehyde functional unit. The Hg2+-selective response of the chemodosimeter was clearly observed in aqueous buffer as well as in human blood plasma medium.

    Original languageEnglish
    Pages (from-to)5958-5961
    Number of pages4
    JournalTetrahedron Letters
    Volume50
    Issue number43
    DOIs
    Publication statusPublished - 2009 Oct 28

    Bibliographical note

    Funding Information:
    This work was supported by the Creative Research Initiative Program of the MEST, SRC (No. R11-2005-008-00000-0 ) and KRF ( KRF-2008-313-C00501 and KRF-2008-313-C00508 ).

    Keywords

    • Chromogenic
    • Coumarin
    • Fluorogenic
    • Mercury ion

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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