Fluorescent Diagnostic Probes in Neurodegenerative Diseases

Jin Zhou, Paramesh Jangili, Subin Son, Myung Sun Ji, Miae Won, Jong Seung Kim

Research output: Contribution to journalReview articlepeer-review

127 Citations (Scopus)

Abstract

Neurodegenerative diseases are debilitating disorders that feature progressive and selective loss of function or structure of anatomically or physiologically associated neuronal systems. Both chronic and acute neurodegenerative diseases are associated with high morbidity and mortality along with the death of neurons in different areas of the brain; moreover, there are few or no effective curative therapy options for treating these disorders. There is an urgent need to diagnose neurodegenerative disease as early as possible, and to distinguish between different disorders with overlapping symptoms that will help to decide the best clinical treatment. Recently, in neurodegenerative disease research, fluorescent-probe-mediated biomarker visualization techniques have been gaining increasing attention for the early diagnosis of neurodegenerative diseases. A survey of fluorescent probes for sensing and imaging biomarkers of neurodegenerative diseases is provided. These imaging probes are categorized based on the different potential biomarkers of various neurodegenerative diseases, and their advantages and disadvantages are discussed. Guides to develop new sensing strategies, recognition mechanisms, as well as the ideal features to further improve neurodegenerative disease fluorescence imaging are also explored.

Original languageEnglish
Article number2001945
JournalAdvanced Materials
Volume32
Issue number51
DOIs
Publication statusPublished - 2020 Dec 22

Bibliographical note

Funding Information:
J.Z., P.J., and S.S. contributed equally to this work. The authors gratefully acknowledge the financial support from the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (CRI Project No. 2018R1A3B1052702, J.S.K.), the Ministry of Education (No. 2017R1D1A1B03030062, M.W.), the Natural Science Foundation of China (No. 21705120), the Project of Shandong Province Higher Educational Outstanding Youth Innovation Team (No. 2019KJM008), and the Shandong Province Government‐Sponsored Overseas Study Project.

Publisher Copyright:
© 2020 Wiley-VCH GmbH

Keywords

  • diagnosis
  • fluorescence imaging
  • fluorescence probes
  • neurodegenerative diseases

ASJC Scopus subject areas

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering

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