Fluorescent Imaging of Reactive Oxygen and Nitrogen Species Associated with Pathophysiological Processes

Ji Ting Hou; Kang Kang Yu; Kyoung Sunwoo; Won Young Kim; Seyoung Koo; Jinyu Wang; Wen Xiu Ren; Shan Wang; Xiao Qi Yu; Jong Seung Kim

doi:10.1016/j.chempr.2019.12.005

Fluorescent Imaging of Reactive Oxygen and Nitrogen Species Associated with Pathophysiological Processes

Ji Ting Hou, Kang Kang Yu, Kyoung Sunwoo, Won Young Kim, Seyoung Koo, Jinyu Wang, Wen Xiu Ren, Shan Wang, Xiao Qi Yu, Jong Seung Kim

Research output: Contribution to journal › Review article › peer-review

157 Citations (Scopus)

Abstract

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play their essential roles in regulating biological events. Their aberrant behaviors are mostly associated with pathophysiological processes. A better understanding of these processes can assuredly help us in examining the pathogenesis and progression of diseases and is beneficial for the ultimate clinical therapy. Numerous fluorescent probes have been developed in the last 5 years for detecting ROS and RNS involved in diverse pathophysiological processes, and these are summarized in this review. Optical properties of the fluorescent probes will be described, and their applications in ROS and RNS detection in pathophysiological models, including in chemical- and bacteria-triggered inflammation, drug-induced organ toxicity, specific diseases, injury of different tissues and organs, and other pathophysiological processes, will be elaborated. Finally, we judiciously highlight the achievement, limitations, and future perspectives in this field.

Original language	English
Pages (from-to)	832-866
Number of pages	35
Journal	Chem
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/j.chempr.2019.12.005
Publication status	Published - 2020 Apr 9

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China ( 21807029 to J.-T.H. and 21877082 to X.-Q.Y.) and the Nanhu Scholars Program for Young Scholars of Xinyang Normal University (S.W.). This work was also supported by the CRI project ( 2018R1A3B1052702 to J.S.K.) of the National Research Foundation of Korea .

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

SDG3: Good health and well-being
diseases
drug-induced organ toxicity
fluorescent sensor
inflammation
injury
pathophysiological processes
reactive nitrogen species
reactive oxygen species

ASJC Scopus subject areas

General Chemistry
Biochemistry
Environmental Chemistry
General Chemical Engineering
Biochemistry, medical
Materials Chemistry

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10.1016/j.chempr.2019.12.005

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title = "Fluorescent Imaging of Reactive Oxygen and Nitrogen Species Associated with Pathophysiological Processes",

abstract = "Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play their essential roles in regulating biological events. Their aberrant behaviors are mostly associated with pathophysiological processes. A better understanding of these processes can assuredly help us in examining the pathogenesis and progression of diseases and is beneficial for the ultimate clinical therapy. Numerous fluorescent probes have been developed in the last 5 years for detecting ROS and RNS involved in diverse pathophysiological processes, and these are summarized in this review. Optical properties of the fluorescent probes will be described, and their applications in ROS and RNS detection in pathophysiological models, including in chemical- and bacteria-triggered inflammation, drug-induced organ toxicity, specific diseases, injury of different tissues and organs, and other pathophysiological processes, will be elaborated. Finally, we judiciously highlight the achievement, limitations, and future perspectives in this field.",

keywords = "SDG3: Good health and well-being, diseases, drug-induced organ toxicity, fluorescent sensor, inflammation, injury, pathophysiological processes, reactive nitrogen species, reactive oxygen species",

author = "Hou, {Ji Ting} and Yu, {Kang Kang} and Kyoung Sunwoo and Kim, {Won Young} and Seyoung Koo and Jinyu Wang and Ren, {Wen Xiu} and Shan Wang and Yu, {Xiao Qi} and Kim, {Jong Seung}",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China ( 21807029 to J.-T.H. and 21877082 to X.-Q.Y.) and the Nanhu Scholars Program for Young Scholars of Xinyang Normal University (S.W.). This work was also supported by the CRI project ( 2018R1A3B1052702 to J.S.K.) of the National Research Foundation of Korea . Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

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doi = "10.1016/j.chempr.2019.12.005",

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AU - Hou, Ji Ting

AU - Yu, Kang Kang

AU - Sunwoo, Kyoung

AU - Kim, Won Young

AU - Koo, Seyoung

AU - Wang, Jinyu

AU - Ren, Wen Xiu

AU - Wang, Shan

AU - Yu, Xiao Qi

AU - Kim, Jong Seung

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China ( 21807029 to J.-T.H. and 21877082 to X.-Q.Y.) and the Nanhu Scholars Program for Young Scholars of Xinyang Normal University (S.W.). This work was also supported by the CRI project ( 2018R1A3B1052702 to J.S.K.) of the National Research Foundation of Korea . Publisher Copyright: © 2019 Elsevier Inc.

PY - 2020/4/9

Y1 - 2020/4/9

N2 - Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play their essential roles in regulating biological events. Their aberrant behaviors are mostly associated with pathophysiological processes. A better understanding of these processes can assuredly help us in examining the pathogenesis and progression of diseases and is beneficial for the ultimate clinical therapy. Numerous fluorescent probes have been developed in the last 5 years for detecting ROS and RNS involved in diverse pathophysiological processes, and these are summarized in this review. Optical properties of the fluorescent probes will be described, and their applications in ROS and RNS detection in pathophysiological models, including in chemical- and bacteria-triggered inflammation, drug-induced organ toxicity, specific diseases, injury of different tissues and organs, and other pathophysiological processes, will be elaborated. Finally, we judiciously highlight the achievement, limitations, and future perspectives in this field.

AB - Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play their essential roles in regulating biological events. Their aberrant behaviors are mostly associated with pathophysiological processes. A better understanding of these processes can assuredly help us in examining the pathogenesis and progression of diseases and is beneficial for the ultimate clinical therapy. Numerous fluorescent probes have been developed in the last 5 years for detecting ROS and RNS involved in diverse pathophysiological processes, and these are summarized in this review. Optical properties of the fluorescent probes will be described, and their applications in ROS and RNS detection in pathophysiological models, including in chemical- and bacteria-triggered inflammation, drug-induced organ toxicity, specific diseases, injury of different tissues and organs, and other pathophysiological processes, will be elaborated. Finally, we judiciously highlight the achievement, limitations, and future perspectives in this field.

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DO - 10.1016/j.chempr.2019.12.005

M3 - Review article

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Fluorescent Imaging of Reactive Oxygen and Nitrogen Species Associated with Pathophysiological Processes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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