Fluorescent Imaging of Reactive Oxygen and Nitrogen Species Associated with Pathophysiological Processes

Ji Ting Hou, Kang Kang Yu, Kyoung Sunwoo, Won Young Kim, Seyoung Koo, Jinyu Wang, Wen Xiu Ren, Shan Wang, Xiao Qi Yu, Jong Seung Kim

Research output: Contribution to journalReview articlepeer-review

137 Citations (Scopus)


Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play their essential roles in regulating biological events. Their aberrant behaviors are mostly associated with pathophysiological processes. A better understanding of these processes can assuredly help us in examining the pathogenesis and progression of diseases and is beneficial for the ultimate clinical therapy. Numerous fluorescent probes have been developed in the last 5 years for detecting ROS and RNS involved in diverse pathophysiological processes, and these are summarized in this review. Optical properties of the fluorescent probes will be described, and their applications in ROS and RNS detection in pathophysiological models, including in chemical- and bacteria-triggered inflammation, drug-induced organ toxicity, specific diseases, injury of different tissues and organs, and other pathophysiological processes, will be elaborated. Finally, we judiciously highlight the achievement, limitations, and future perspectives in this field.

Original languageEnglish
Pages (from-to)832-866
Number of pages35
Issue number4
Publication statusPublished - 2020 Apr 9

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China ( 21807029 to J.-T.H. and 21877082 to X.-Q.Y.) and the Nanhu Scholars Program for Young Scholars of Xinyang Normal University (S.W.). This work was also supported by the CRI project ( 2018R1A3B1052702 to J.S.K.) of the National Research Foundation of Korea .

Publisher Copyright:
© 2019 Elsevier Inc.


  • SDG3: Good health and well-being
  • diseases
  • drug-induced organ toxicity
  • fluorescent sensor
  • inflammation
  • injury
  • pathophysiological processes
  • reactive nitrogen species
  • reactive oxygen species

ASJC Scopus subject areas

  • General Chemistry
  • Biochemistry
  • Environmental Chemistry
  • General Chemical Engineering
  • Biochemistry, medical
  • Materials Chemistry


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