Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection

Jaemoon Yang, Eun Kyung Lim, Hong Jae Lee, Joseph Park, Sang Cheon Lee, Kwangyeol Lee, Ho Geun Yoon, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

    Research output: Contribution to journalArticlepeer-review

    92 Citations (Scopus)

    Abstract

    Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe2O4 magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.

    Original languageEnglish
    Pages (from-to)2548-2555
    Number of pages8
    JournalBiomaterials
    Volume29
    Issue number16
    DOIs
    Publication statusPublished - 2008 Jun

    Bibliographical note

    Funding Information:
    This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (M10755020001-07N5502-00110, R15-2004-024-00000-0 and R01-2006-000-10023-0), the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (0620190-1).

    Keywords

    • Cancer
    • Cetuximab
    • Fluorescence
    • Magnetic nanoparticle
    • Nanohybrid

    ASJC Scopus subject areas

    • Biophysics
    • Bioengineering
    • Ceramics and Composites
    • Biomaterials
    • Mechanics of Materials

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