Abstract
Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe2O4 magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.
Original language | English |
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Pages (from-to) | 2548-2555 |
Number of pages | 8 |
Journal | Biomaterials |
Volume | 29 |
Issue number | 16 |
DOIs | |
Publication status | Published - 2008 Jun |
Bibliographical note
Funding Information:This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (M10755020001-07N5502-00110, R15-2004-024-00000-0 and R01-2006-000-10023-0), the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (0620190-1).
Keywords
- Cancer
- Cetuximab
- Fluorescence
- Magnetic nanoparticle
- Nanohybrid
ASJC Scopus subject areas
- Biophysics
- Bioengineering
- Ceramics and Composites
- Biomaterials
- Mechanics of Materials