Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection

Jaemoon Yang; Eun Kyung Lim; Hong Jae Lee; Joseph Park; Sang Cheon Lee; Kwangyeol Lee; Ho Geun Yoon; Jin Suck Suh; Yong Min Huh; Seungjoo Haam

doi:10.1016/j.biomaterials.2007.12.036

Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection

Jaemoon Yang, Eun Kyung Lim, Hong Jae Lee, Joseph Park, Sang Cheon Lee, Kwangyeol Lee, Ho Geun Yoon, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

Abstract

Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe₂O₄ magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.

Original language	English
Pages (from-to)	2548-2555
Number of pages	8
Journal	Biomaterials
Volume	29
Issue number	16
DOIs	https://doi.org/10.1016/j.biomaterials.2007.12.036
Publication status	Published - 2008 Jun

Bibliographical note

Funding Information:
This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (M10755020001-07N5502-00110, R15-2004-024-00000-0 and R01-2006-000-10023-0), the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (0620190-1).

Keywords

Cancer
Cetuximab
Fluorescence
Magnetic nanoparticle
Nanohybrid

ASJC Scopus subject areas

Biophysics
Bioengineering
Ceramics and Composites
Biomaterials
Mechanics of Materials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biomaterials.2007.12.036

Cite this

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title = "Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection",

abstract = "Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe2O4 magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.",

keywords = "Cancer, Cetuximab, Fluorescence, Magnetic nanoparticle, Nanohybrid",

author = "Jaemoon Yang and Lim, {Eun Kyung} and Lee, {Hong Jae} and Joseph Park and Lee, {Sang Cheon} and Kwangyeol Lee and Yoon, {Ho Geun} and Suh, {Jin Suck} and Huh, {Yong Min} and Seungjoo Haam",

note = "Funding Information: This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (M10755020001-07N5502-00110, R15-2004-024-00000-0 and R01-2006-000-10023-0), the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (0620190-1). ",

year = "2008",

month = jun,

doi = "10.1016/j.biomaterials.2007.12.036",

language = "English",

volume = "29",

pages = "2548--2555",

journal = "Biomaterials",

issn = "0142-9612",

publisher = "Elsevier Ltd",

number = "16",

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TY - JOUR

T1 - Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection

AU - Yang, Jaemoon

AU - Lim, Eun Kyung

AU - Lee, Hong Jae

AU - Park, Joseph

AU - Lee, Sang Cheon

AU - Lee, Kwangyeol

AU - Yoon, Ho Geun

AU - Suh, Jin Suck

AU - Huh, Yong Min

AU - Haam, Seungjoo

N1 - Funding Information: This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (M10755020001-07N5502-00110, R15-2004-024-00000-0 and R01-2006-000-10023-0), the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (0620190-1).

PY - 2008/6

Y1 - 2008/6

N2 - Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe2O4 magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.

AB - Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe2O4 magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.

KW - Cancer

KW - Cetuximab

KW - Fluorescence

KW - Magnetic nanoparticle

KW - Nanohybrid

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U2 - 10.1016/j.biomaterials.2007.12.036

DO - 10.1016/j.biomaterials.2007.12.036

M3 - Article

C2 - 18329706

AN - SCOPUS:40949116615

SN - 0142-9612

VL - 29

SP - 2548

EP - 2555

JO - Biomaterials

JF - Biomaterials

IS - 16

ER -

Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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