Fluorescent Molecular Rotors for Viscosity Sensors

Seung Chul Lee; Jeongyun Heo; Hee Chul Woo; Ji Ah Lee; Young Hun Seo; Chang Lyoul Lee; Sehoon Kim; O. Pil Kwon

doi:10.1002/chem.201801389

Fluorescent Molecular Rotors for Viscosity Sensors

Seung Chul Lee, Jeongyun Heo, Hee Chul Woo, Ji Ah Lee, Young Hun Seo, Chang Lyoul Lee, Sehoon Kim, O. Pil Kwon

KU-KIST Graduate School of Converging Science and Technology

Research output: Contribution to journal › Review article › peer-review

157 Citations (Scopus)

Abstract

Fluorescent molecular rotors (FMRs) can act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In FMRs, the rotation of rotators connected to a fluorescent π-conjugated bridge is suppressed by increasing environmental viscosity, resulting in increasing fluorescence (FL) intensity. In this minireview, we describe recently developed FMRs including push–pull type π-conjugated chromophores, meso-phenyl (borondipyrromethene) (BODIPY) derivatives, dioxaborine derivatives, cyanine derivatives, and porphyrin derivatives whose FL mechanism is viscosity-responsive. In addition, FMR design strategies for addressing various issues (e.g., obtaining high FL contrast, internal FL references, and FL intensity-contrast trade-off) and their biological and microfluidic applications are also discussed.

Original language	English
Pages (from-to)	13706-13718
Number of pages	13
Journal	Chemistry - A European Journal
Volume	24
Issue number	52
DOIs	https://doi.org/10.1002/chem.201801389
Publication status	Published - 2018 Sept 18

Bibliographical note

Funding Information:
O.-P. K. thanks the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning and Ministry of Education, Korea (No. 2014R1A5A1009799 and 2009-0093826). C.-L. L. thanks the National Research Foundation of Korea (NRF) for financial support through a grant funded by the Korean government (MSIP; NRF2016R1A2B4013003) and a grant funded by GIST 2018 (Research on Advanced Optical Science and Technology). S. K. thanks the Korea Health Industry Development Institute (HI15C1540), and Korea Research Institute of Standards and Science (Development of Platform Technology for Innovative Medical Measurements Program, KRISS-2017-GP2017-0020) for financial supports.

Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

fluorescence dynamics
fluorescent molecular rotors
microviscosity
molecular rotors
viscosity sensors

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1002/chem.201801389

Cite this

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title = "Fluorescent Molecular Rotors for Viscosity Sensors",

abstract = "Fluorescent molecular rotors (FMRs) can act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In FMRs, the rotation of rotators connected to a fluorescent π-conjugated bridge is suppressed by increasing environmental viscosity, resulting in increasing fluorescence (FL) intensity. In this minireview, we describe recently developed FMRs including push–pull type π-conjugated chromophores, meso-phenyl (borondipyrromethene) (BODIPY) derivatives, dioxaborine derivatives, cyanine derivatives, and porphyrin derivatives whose FL mechanism is viscosity-responsive. In addition, FMR design strategies for addressing various issues (e.g., obtaining high FL contrast, internal FL references, and FL intensity-contrast trade-off) and their biological and microfluidic applications are also discussed.",

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author = "Lee, {Seung Chul} and Jeongyun Heo and Woo, {Hee Chul} and Lee, {Ji Ah} and Seo, {Young Hun} and Lee, {Chang Lyoul} and Sehoon Kim and Kwon, {O. Pil}",

note = "Funding Information: O.-P. K. thanks the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning and Ministry of Education, Korea (No. 2014R1A5A1009799 and 2009-0093826). C.-L. L. thanks the National Research Foundation of Korea (NRF) for financial support through a grant funded by the Korean government (MSIP; NRF2016R1A2B4013003) and a grant funded by GIST 2018 (Research on Advanced Optical Science and Technology). S. K. thanks the Korea Health Industry Development Institute (HI15C1540), and Korea Research Institute of Standards and Science (Development of Platform Technology for Innovative Medical Measurements Program, KRISS-2017-GP2017-0020) for financial supports. Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

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AU - Lee, Seung Chul

AU - Heo, Jeongyun

AU - Woo, Hee Chul

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AU - Seo, Young Hun

AU - Lee, Chang Lyoul

AU - Kim, Sehoon

AU - Kwon, O. Pil

N1 - Funding Information: O.-P. K. thanks the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning and Ministry of Education, Korea (No. 2014R1A5A1009799 and 2009-0093826). C.-L. L. thanks the National Research Foundation of Korea (NRF) for financial support through a grant funded by the Korean government (MSIP; NRF2016R1A2B4013003) and a grant funded by GIST 2018 (Research on Advanced Optical Science and Technology). S. K. thanks the Korea Health Industry Development Institute (HI15C1540), and Korea Research Institute of Standards and Science (Development of Platform Technology for Innovative Medical Measurements Program, KRISS-2017-GP2017-0020) for financial supports. Publisher Copyright: © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2018/9/18

Y1 - 2018/9/18

N2 - Fluorescent molecular rotors (FMRs) can act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In FMRs, the rotation of rotators connected to a fluorescent π-conjugated bridge is suppressed by increasing environmental viscosity, resulting in increasing fluorescence (FL) intensity. In this minireview, we describe recently developed FMRs including push–pull type π-conjugated chromophores, meso-phenyl (borondipyrromethene) (BODIPY) derivatives, dioxaborine derivatives, cyanine derivatives, and porphyrin derivatives whose FL mechanism is viscosity-responsive. In addition, FMR design strategies for addressing various issues (e.g., obtaining high FL contrast, internal FL references, and FL intensity-contrast trade-off) and their biological and microfluidic applications are also discussed.

AB - Fluorescent molecular rotors (FMRs) can act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In FMRs, the rotation of rotators connected to a fluorescent π-conjugated bridge is suppressed by increasing environmental viscosity, resulting in increasing fluorescence (FL) intensity. In this minireview, we describe recently developed FMRs including push–pull type π-conjugated chromophores, meso-phenyl (borondipyrromethene) (BODIPY) derivatives, dioxaborine derivatives, cyanine derivatives, and porphyrin derivatives whose FL mechanism is viscosity-responsive. In addition, FMR design strategies for addressing various issues (e.g., obtaining high FL contrast, internal FL references, and FL intensity-contrast trade-off) and their biological and microfluidic applications are also discussed.

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Fluorescent Molecular Rotors for Viscosity Sensors

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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