A new fluorescein derivative has been synthesized for the detection of pyrophosphate (PPi) and ATP in 100% aqueous solution. Chemosensor 1 in the presence of Mn2+ (2.5 equiv) displayed selective fluorescent enhancements with PPi and ATP at pH 7.4. among the anions examined. The association constant of 1 in the presence of Mn2+ with PPi and ATP was calculated as 4.2 × 104 and 3.5 × 104 M-1.
Bibliographical noteFunding Information:
This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant (NRL) funded by the Korean government (MOST) (R04-2007-000-2007-0), the SRC program of the KOSEF (R11-2005-008-02001-0), Korea Ministry of Environment as ‘The Eco-technopia 21 project’ and BK21.
Copyright 2008 Elsevier B.V., All rights reserved.
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry