Fluorescent turn-on Zn 2+ sensing in aqueous and cellular media

Sumin Lee, Jae Hong Lee, Tuhin Pradhan, Chang Su Lim, Bong-Rae Cho, Sankarprasad Bhuniya, Sungtae Kim, Jong Seung Kim

    Research output: Contribution to journalArticlepeer-review

    54 Citations (Scopus)

    Abstract

    A naphthalimide-based water soluble Zn 2+ sensor bearing polyamino carboxylate as a metal chelating moiety was synthesized and its application for the selective detection of Zn 2+ ion in 100% aqueous solution is demonstrated. The newly developed fluorescent sensor exhibits selective binding affinity towards Zn 2+ and pH insensitivity in biologically relevant range. Confocal fluorescent microscopy images indicate that this probe works effectively for intracellular Zn 2+ imaging with high cell permeability.

    Original languageEnglish
    Pages (from-to)1489-1493
    Number of pages5
    JournalSensors and Actuators, B: Chemical
    Volume160
    Issue number1
    DOIs
    Publication statusPublished - 2011 Dec 15

    Keywords

    • Cell imaging
    • DFT calculations
    • Fluorescent sensor
    • Zinc

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Instrumentation
    • Condensed Matter Physics
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Electrical and Electronic Engineering
    • Materials Chemistry

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