Fluorescent turn-on Zn 2+ sensing in aqueous and cellular media

Sumin Lee; Jae Hong Lee; Tuhin Pradhan; Chang Su Lim; Bong-Rae Cho; Sankarprasad Bhuniya; Sungtae Kim; Jong Seung Kim

doi:10.1016/j.snb.2011.07.065

Fluorescent turn-on Zn ²⁺ sensing in aqueous and cellular media

Sumin Lee, Jae Hong Lee, Tuhin Pradhan, Chang Su Lim, Bong-Rae Cho, Sankarprasad Bhuniya, Sungtae Kim, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

A naphthalimide-based water soluble Zn ²⁺ sensor bearing polyamino carboxylate as a metal chelating moiety was synthesized and its application for the selective detection of Zn ²⁺ ion in 100% aqueous solution is demonstrated. The newly developed fluorescent sensor exhibits selective binding affinity towards Zn ²⁺ and pH insensitivity in biologically relevant range. Confocal fluorescent microscopy images indicate that this probe works effectively for intracellular Zn ²⁺ imaging with high cell permeability.

Original language	English
Pages (from-to)	1489-1493
Number of pages	5
Journal	Sensors and Actuators, B: Chemical
Volume	160
Issue number	1
DOIs	https://doi.org/10.1016/j.snb.2011.07.065
Publication status	Published - 2011 Dec 15

Keywords

Cell imaging
DFT calculations
Fluorescent sensor
Zinc

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

Access to Document

10.1016/j.snb.2011.07.065

Cite this

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abstract = "A naphthalimide-based water soluble Zn 2+ sensor bearing polyamino carboxylate as a metal chelating moiety was synthesized and its application for the selective detection of Zn 2+ ion in 100% aqueous solution is demonstrated. The newly developed fluorescent sensor exhibits selective binding affinity towards Zn 2+ and pH insensitivity in biologically relevant range. Confocal fluorescent microscopy images indicate that this probe works effectively for intracellular Zn 2+ imaging with high cell permeability.",

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AU - Lee, Jae Hong

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AU - Bhuniya, Sankarprasad

AU - Kim, Sungtae

AU - Kim, Jong Seung

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KW - DFT calculations

KW - Fluorescent sensor

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