Focal fat deposition at liver MRI with gadobenate dimeglumine and gadoxetic acid: Quantitative and qualitative analysis

Suk Keu Yeom, Jae Ho Byun, Hye Jin Kim, Seong Ho Park, Namkug Kim, Yong Moon Shin, Pyo Nyun Kim

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Objective: To evaluate the image findings of focal fat deposition (FFD) in the liver on gadobenate dimeglumine (Gd-BOPTA)- and gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI, particularly during the hepatobiliary phase (HBP), and the relationship between relative enhancement (RE) and fat signal fraction (FSF) of FFD. Subjects and Methods: Twenty-one patients with 27 FFDs (mean diameter, 21.9mm), which showed low signal intensity on opposed-phase compared with in-phase MRI, were retrospectively evaluated. RE of the liver (REliver) and FFD (REFFD) and liver-to-lesion contrast-to-noise ratio (CNR) of FFD were measured on dynamic phases and HBP images with fat-saturated in-phase gradient-echo sequence. The FSF of each FFD was measured on in- and opposed-phase dual gradient-echo images. We qualitatively analyzed imaging findings of FFDs, including signal intensity, shape, margin, and homogeneity on HBP images, and enhancement pattern during dynamic phases. The correlations between REFFD and FSF and between CNR and FSF on HBP images were evaluated using Pearson's correlation tests and a simple linear regression model. Results: There were no significant differences between REFFD and REliver in dynamic phases and HBP, regardless of contrast agents (p≥0.075). On HBP images, CNR (p=0.008) but not REFFD (p=0.122) was significantly correlated with FSF of FFDs (mean FSF, 19%). On HBP images, 21 of the 27 (77.8%) FFDs were hypointense, and 17 (63%) were homogeneous. Of the 21 hypointense FFDs, 12 (57.1%) had an ovoid shape and 11 (52.4%) were well margined. Although the 27 FFDs showed various enhancement patterns, 17 (63%) showed no enhancement. Conclusion: Most FFDs appeared as hypointense lesions on Gd-BOPTA- and Gd-EOB-DTPA-enhanced MRI during HBP, with various enhancement patterns during dynamic contrast-enhanced phases. REFFD on HBP images was not significantly correlated with FSF of low grade FFDs.

Original languageEnglish
Pages (from-to)911-917
Number of pages7
JournalMagnetic Resonance Imaging
Issue number6
Publication statusPublished - 2013 Jul
Externally publishedYes

Bibliographical note

Copyright 2014 Elsevier B.V., All rights reserved.


  • Focal fat deposition
  • Gd-BOPTA
  • Liver
  • MRI

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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