Folate-modified-chitosan-coated liposomes for tumor-targeted drug delivery

Kui Kun Yang, Ming Kong, Ya Nan Wei, Ya Liu, Xiao Jie Cheng, Jing Li, Hyun Jin Park, Xi Guang Chen

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

In this study, a folate-modified-chitosan-coated liposome (FCCL) was prepared for tumor-targeted drug delivery. The folate-chitosan conjugates were characterized using 1H NMR and infrared spectrum analysis. The properties of folate-chitosan-coated liposomes (FCCLs) were studied and compared with those of traditional liposomes and chitosan-coated liposomes (CCLs). FCCLs were spherical in shape with a classic core-shell structure. Compared with conventional liposomes, FCCLs had larger size (average diameter: 182.0 nm), higher zeta potential (10.1 mV), prolonged drug release behaviors (55.76 % after 24 h), and better physical stability when stored at 25 C, all similar to the properties of CCLs. With fluorescein as a model drug, fluorescein-loaded liposomes, CCLs, and FCCLs were prepared and their tumor targeting ability was evaluated according to the in vitro cellular uptake of fluorescein loaded nanoparticles by MCF-7 and HUVEC cells. Results demonstrated that FCCLs had a significant higher uptake by folate receptor positive cells (MCF-7) as compared to traditional liposomes and CCLs, which indicated that the FCCLs were promising nano-carriers for tumor-targeted drug delivery.

Original languageEnglish
Pages (from-to)1717-1728
Number of pages12
JournalJournal of Materials Science
Volume48
Issue number4
DOIs
Publication statusPublished - 2013 Feb

Bibliographical note

Funding Information:
Acknowledgements This research was granted by Science and Technology Breakthrough Project (2011GSF12124), National Natural Science Foundation of China (81071274) and International Science and Technology Cooperation Project (2011DFA31270).

ASJC Scopus subject areas

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering

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