Fork-shaped neural interface with multichannel high spatial selectivity in the peripheral nerve of a rat

Wonsuk Choi, Hyung Dal Park, Seonghwan Oh, Jeong Hyun Hong, Junesun Kim, Dae Sung Yoon, Jinseok Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. This study aims to develop and validate a sophisticated fork-shaped neural interface (FNI) designed for peripheral nerves, focusing on achieving high spatial resolution, functional selectivity, and improved charge storage capacities. The objective is to create a neurointerface capable of precise neuroanatomical analysis, neural signal recording, and stimulation. Approach. Our approach involves the design and implementation of the FNI, which integrates 32 multichannel working electrodes featuring enhanced charge storage capacities and low impedance. An insertion guide holder is incorporated to refine neuronal selectivity. The study employs meticulous electrode placement, bipolar electrical stimulation, and comprehensive analysis of induced neural responses to verify the FNI’s capabilities. Stability over an eight-week period is a crucial aspect, ensuring the reliability and durability of the neural interface. Main results. The FNI demonstrated remarkable efficacy in neuroanatomical analysis, exhibiting accurate positioning of motor nerves and successfully inducing various movements. Stable impedance values were maintained over the eight-week period, affirming the durability of the FNI. Additionally, the neural interface proved effective in recording sensory signals from different hind limb areas. The advanced charge storage capacities and low impedance contribute to the FNI’s robust performance, establishing its potential for prolonged use. Significance. This research represents a significant advancement in neural interface technology, offering a versatile tool with broad applications in neuroscience and neuroengineering. The FNI’s ability to capture both motor and sensory neural activity positions it as a comprehensive solution for neuroanatomical studies. Moreover, the precise neuromodulation potential of the FNI holds promise for applications in advanced bionic prosthetic control and therapeutic interventions. The study’s findings contribute to the evolving field of neuroengineering, paving the way for enhanced understanding and manipulation of peripheral neural functions.

Original languageEnglish
Article number026004
JournalJournal of Neural Engineering
Volume21
Issue number2
DOIs
Publication statusPublished - 2024 Apr 1

Bibliographical note

Publisher Copyright:
© 2024 IOP Publishing Ltd.

Keywords

  • flexible neural electrodes
  • neural signal recording
  • neural stimulation
  • peripheral neural interface

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cellular and Molecular Neuroscience

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