Fractal-shaped droplet microfluidics for highly scalable cell mechanoporation

Myungsuk Sung; Dalei Jing; Byeongju Joo; Sungbin Im; You Jeong Kim; Yi Sui; Aram J. Chung

doi:10.1039/d5lc00865d

Fractal-shaped droplet microfluidics for highly scalable cell mechanoporation

Myungsuk Sung
, Dalei Jing
, Byeongju Joo
, Sungbin Im
, You Jeong Kim
, Yi Sui
, Aram J. Chung^*

^*Corresponding author for this work

School of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Emerging non-viral gene delivery platforms provide alternatives to viral methods. However, they remain limited in scalability and efficiency for clinical translation. We present a fractal-shaped droplet microfluidic system that achieves approximately 98% efficiency and 80% viability at throughputs exceeding 10⁷ cells per min, enabling efficient, large-scale, and clinically relevant cell engineering.

Original language	English
Pages (from-to)	10-17
Number of pages	8
Journal	Lab on a Chip
Volume	26
Issue number	1
DOIs	https://doi.org/10.1039/d5lc00865d
Publication status	Published - 2026 Jan 6

Bibliographical note

Publisher Copyright:
This journal is © The Royal Society of Chemistry, 2026

ASJC Scopus subject areas

Bioengineering
General Chemistry
Biochemistry
Biomedical Engineering

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10.1039/d5lc00865d

Cite this

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abstract = "Emerging non-viral gene delivery platforms provide alternatives to viral methods. However, they remain limited in scalability and efficiency for clinical translation. We present a fractal-shaped droplet microfluidic system that achieves approximately 98\% efficiency and 80\% viability at throughputs exceeding 107 cells per min, enabling efficient, large-scale, and clinically relevant cell engineering.",

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AU - Sung, Myungsuk

AU - Jing, Dalei

AU - Joo, Byeongju

AU - Im, Sungbin

AU - Kim, You Jeong

AU - Sui, Yi

AU - Chung, Aram J.

PY - 2026/1/6

Y1 - 2026/1/6

N2 - Emerging non-viral gene delivery platforms provide alternatives to viral methods. However, they remain limited in scalability and efficiency for clinical translation. We present a fractal-shaped droplet microfluidic system that achieves approximately 98% efficiency and 80% viability at throughputs exceeding 107 cells per min, enabling efficient, large-scale, and clinically relevant cell engineering.

AB - Emerging non-viral gene delivery platforms provide alternatives to viral methods. However, they remain limited in scalability and efficiency for clinical translation. We present a fractal-shaped droplet microfluidic system that achieves approximately 98% efficiency and 80% viability at throughputs exceeding 107 cells per min, enabling efficient, large-scale, and clinically relevant cell engineering.

UR - https://www.scopus.com/pages/publications/105024782801

U2 - 10.1039/d5lc00865d

DO - 10.1039/d5lc00865d

M3 - Article

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AN - SCOPUS:105024782801

SN - 1473-0197

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JO - Lab on a Chip

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Fractal-shaped droplet microfluidics for highly scalable cell mechanoporation

Abstract

Bibliographical note

ASJC Scopus subject areas

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