Frontoparietal cortical thinning in respiratory-type panic disorder: A preliminary report

Ho Kyoung Yoon, June Kang, Do Young Kwon, Byung Joo Ham

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Objective: Many evidences raise the possibility that the panic disorder (PD) patients with respiratory subtype (RS) may have characteristic structural abnormalities. We aimed to explore the structural differences between PD patients with and without the respiratory symptoms. Methods: Patients with PD were recruited from the Department of Psychiatry at Korea University Anam Hospital. Respiratory subtype (RS) was diagnosed when at least 4 out of 5 of the following respiratory symptoms were present during the panic attack: fear of dying, chest pain/discomfort, shortness of breath, paresthesias, and a choking sensation. We acquired high-resolution MRI scans and used Free Surfer to obtain a measure of cortical thickness for each patient. Results: Cluster based analysis revealed significantly decreased cortical thickness in the left hemisphere in the caudal-middle-frontal, superior frontal, and posterior parietal areas in the RS group. No significant difference was observed in any of the limbic areas. Conclusion: Respiratory symptoms of panic disorder were associated with a reduction in cortical thickness in the left frontal and parietal areas. This finding leads to the assumption that the frontoparietal network is the crucial component in a larger cortical network underlying the perception of dyspnea in RS.

Original languageEnglish
Pages (from-to)146-151
Number of pages6
JournalPsychiatry Investigation
Issue number1
Publication statusPublished - 2016 Jan

Bibliographical note

Publisher Copyright:
© 2016 Korean Neuropsychiatric Association.


  • Cortical thickness
  • FreeSurfer
  • Panic disorder
  • Respiratory type

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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