Fullerene attachment enhances performance of a DNA nanomachine

Su Ryon Shin; Kyeong Sik Jin; Chang Kee Lee; Sun I. Kim; Geoffrey M. Spinks; Insuk So; Ju Hong Jeon; Tong Mook Kang; Ji Young Mun; Sung Sik Han; Moonhor Ree; Seon Jeong Kim

doi:10.1002/adma.200803429

Fullerene attachment enhances performance of a DNA nanomachine

Su Ryon Shin, Kyeong Sik Jin, Chang Kee Lee, Sun I. Kim, Geoffrey M. Spinks, Insuk So, Ju Hong Jeon, Tong Mook Kang, Ji Young Mun, Sung Sik Han, Moonhor Ree, Seon Jeong Kim

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

The attachment of fullerenes to a DNA motif significantly improves the molecular switching and stability of pH driven enthalpic molecular machine has been reported. DNA is considered as a versatile building block for molecular machines because of its well defined structure and controllable intermolecular interactions. The pH-induced transformation of the DNA was confirmed by Circular Dichroism (CD) spectroscopy and changes occurring in DNA motif were analyzed using three-dimensional molecular analysis by Small Angle X-ray Scattering (SAXS). Hydrophobic interactions between the terminal fullerenes in the folded i-motif conformation increased the machines power stroke and force generated. No reduction in cycling speed or cycling stability with changing pH was observed as a result of attachment of the fullerene.

Original language	English
Pages (from-to)	1907-1910
Number of pages	4
Journal	Advanced Materials
Volume	21
Issue number	19
DOIs	https://doi.org/10.1002/adma.200803429
Publication status	Published - 2009 May 18

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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title = "Fullerene attachment enhances performance of a DNA nanomachine",

abstract = "The attachment of fullerenes to a DNA motif significantly improves the molecular switching and stability of pH driven enthalpic molecular machine has been reported. DNA is considered as a versatile building block for molecular machines because of its well defined structure and controllable intermolecular interactions. The pH-induced transformation of the DNA was confirmed by Circular Dichroism (CD) spectroscopy and changes occurring in DNA motif were analyzed using three-dimensional molecular analysis by Small Angle X-ray Scattering (SAXS). Hydrophobic interactions between the terminal fullerenes in the folded i-motif conformation increased the machines power stroke and force generated. No reduction in cycling speed or cycling stability with changing pH was observed as a result of attachment of the fullerene.",

author = "Shin, {Su Ryon} and Jin, {Kyeong Sik} and Lee, {Chang Kee} and Kim, {Sun I.} and Spinks, {Geoffrey M.} and Insuk So and Jeon, {Ju Hong} and Kang, {Tong Mook} and Mun, {Ji Young} and Han, {Sung Sik} and Moonhor Ree and Kim, {Seon Jeong}",

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T1 - Fullerene attachment enhances performance of a DNA nanomachine

AU - Shin, Su Ryon

AU - Jin, Kyeong Sik

AU - Lee, Chang Kee

AU - Kim, Sun I.

AU - Spinks, Geoffrey M.

AU - So, Insuk

AU - Jeon, Ju Hong

AU - Kang, Tong Mook

AU - Mun, Ji Young

AU - Han, Sung Sik

AU - Ree, Moonhor

AU - Kim, Seon Jeong

PY - 2009/5/18

Y1 - 2009/5/18

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AB - The attachment of fullerenes to a DNA motif significantly improves the molecular switching and stability of pH driven enthalpic molecular machine has been reported. DNA is considered as a versatile building block for molecular machines because of its well defined structure and controllable intermolecular interactions. The pH-induced transformation of the DNA was confirmed by Circular Dichroism (CD) spectroscopy and changes occurring in DNA motif were analyzed using three-dimensional molecular analysis by Small Angle X-ray Scattering (SAXS). Hydrophobic interactions between the terminal fullerenes in the folded i-motif conformation increased the machines power stroke and force generated. No reduction in cycling speed or cycling stability with changing pH was observed as a result of attachment of the fullerene.

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Fullerene attachment enhances performance of a DNA nanomachine

Abstract

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