Fullerene attachment enhances performance of a DNA nanomachine

Su Ryon Shin, Kyeong Sik Jin, Chang Kee Lee, Sun I. Kim, Geoffrey M. Spinks, Insuk So, Ju Hong Jeon, Tong Mook Kang, Ji Young Mun, Sung Sik Han, Moonhor Ree, Seon Jeong Kim

    Research output: Contribution to journalArticlepeer-review

    52 Citations (Scopus)

    Abstract

    The attachment of fullerenes to a DNA motif significantly improves the molecular switching and stability of pH driven enthalpic molecular machine has been reported. DNA is considered as a versatile building block for molecular machines because of its well defined structure and controllable intermolecular interactions. The pH-induced transformation of the DNA was confirmed by Circular Dichroism (CD) spectroscopy and changes occurring in DNA motif were analyzed using three-dimensional molecular analysis by Small Angle X-ray Scattering (SAXS). Hydrophobic interactions between the terminal fullerenes in the folded i-motif conformation increased the machines power stroke and force generated. No reduction in cycling speed or cycling stability with changing pH was observed as a result of attachment of the fullerene.

    Original languageEnglish
    Pages (from-to)1907-1910
    Number of pages4
    JournalAdvanced Materials
    Volume21
    Issue number19
    DOIs
    Publication statusPublished - 2009 May 18

    ASJC Scopus subject areas

    • General Materials Science
    • Mechanics of Materials
    • Mechanical Engineering

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