Function of Fimsbactin B as an Acinetobacter-Selective Antibiotic Delivery Vehicle

Do Young Kim, Hak Joong Kim

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    The ability of fimsbactin B, a natural siderophore of Acinetobacter baumannii, to function as an antibiotic delivery vehicle was investigated by synthesizing three structurally diversified fimsbactin B-cefaclor conjugates. Their antimicrobial activities were Acinetobacter-selective and up to 128-fold more potent than that of cefaclor alone. This activity enhancement originated from the fimsbactin-B-dependent active uptake of cefaclor. Thus, fimsbactin-B-based antibiotic delivery can be an effective approach in combating antibiotic-resistant Acinetobacter infections.

    Original languageEnglish
    Pages (from-to)5256-5260
    Number of pages5
    JournalOrganic Letters
    Volume23
    Issue number13
    DOIs
    Publication statusPublished - 2021 Jul 2

    Bibliographical note

    Funding Information:
    This work was supported by grants from the Korea Centers for Disease Control and Prevention, Ministry of Health and Welfare, Republic of Korea (2019-ER5401-00), the National Research Foundation of Korea (NRF-2018R1D1A1A02086039), and the Korea Basic Science Institute (KBSI) National Research Facilities & Equipment Center (NFEC), funded by the Korean government (Ministry of Education) (2019R1A6C1010028).

    Publisher Copyright:
    © 2021 American Chemical Society.

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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