Abstract
The ability of fimsbactin B, a natural siderophore of Acinetobacter baumannii, to function as an antibiotic delivery vehicle was investigated by synthesizing three structurally diversified fimsbactin B-cefaclor conjugates. Their antimicrobial activities were Acinetobacter-selective and up to 128-fold more potent than that of cefaclor alone. This activity enhancement originated from the fimsbactin-B-dependent active uptake of cefaclor. Thus, fimsbactin-B-based antibiotic delivery can be an effective approach in combating antibiotic-resistant Acinetobacter infections.
Original language | English |
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Pages (from-to) | 5256-5260 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 23 |
Issue number | 13 |
DOIs | |
Publication status | Published - 2021 Jul 2 |
Bibliographical note
Funding Information:This work was supported by grants from the Korea Centers for Disease Control and Prevention, Ministry of Health and Welfare, Republic of Korea (2019-ER5401-00), the National Research Foundation of Korea (NRF-2018R1D1A1A02086039), and the Korea Basic Science Institute (KBSI) National Research Facilities & Equipment Center (NFEC), funded by the Korean government (Ministry of Education) (2019R1A6C1010028).
Publisher Copyright:
© 2021 American Chemical Society.
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry