Function of Fimsbactin B as an Acinetobacter-Selective Antibiotic Delivery Vehicle

Do Young Kim; Hak Joong Kim

doi:10.1021/acs.orglett.1c01786

Function of Fimsbactin B as an Acinetobacter-Selective Antibiotic Delivery Vehicle

Do Young Kim, Hak Joong Kim

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The ability of fimsbactin B, a natural siderophore of Acinetobacter baumannii, to function as an antibiotic delivery vehicle was investigated by synthesizing three structurally diversified fimsbactin B-cefaclor conjugates. Their antimicrobial activities were Acinetobacter-selective and up to 128-fold more potent than that of cefaclor alone. This activity enhancement originated from the fimsbactin-B-dependent active uptake of cefaclor. Thus, fimsbactin-B-based antibiotic delivery can be an effective approach in combating antibiotic-resistant Acinetobacter infections.

Original language	English
Pages (from-to)	5256-5260
Number of pages	5
Journal	Organic Letters
Volume	23
Issue number	13
DOIs	https://doi.org/10.1021/acs.orglett.1c01786
Publication status	Published - 2021 Jul 2

Bibliographical note

Funding Information:
This work was supported by grants from the Korea Centers for Disease Control and Prevention, Ministry of Health and Welfare, Republic of Korea (2019-ER5401-00), the National Research Foundation of Korea (NRF-2018R1D1A1A02086039), and the Korea Basic Science Institute (KBSI) National Research Facilities & Equipment Center (NFEC), funded by the Korean government (Ministry of Education) (2019R1A6C1010028).

Publisher Copyright:
© 2021 American Chemical Society.

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.1c01786

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abstract = "The ability of fimsbactin B, a natural siderophore of Acinetobacter baumannii, to function as an antibiotic delivery vehicle was investigated by synthesizing three structurally diversified fimsbactin B-cefaclor conjugates. Their antimicrobial activities were Acinetobacter-selective and up to 128-fold more potent than that of cefaclor alone. This activity enhancement originated from the fimsbactin-B-dependent active uptake of cefaclor. Thus, fimsbactin-B-based antibiotic delivery can be an effective approach in combating antibiotic-resistant Acinetobacter infections.",

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AB - The ability of fimsbactin B, a natural siderophore of Acinetobacter baumannii, to function as an antibiotic delivery vehicle was investigated by synthesizing three structurally diversified fimsbactin B-cefaclor conjugates. Their antimicrobial activities were Acinetobacter-selective and up to 128-fold more potent than that of cefaclor alone. This activity enhancement originated from the fimsbactin-B-dependent active uptake of cefaclor. Thus, fimsbactin-B-based antibiotic delivery can be an effective approach in combating antibiotic-resistant Acinetobacter infections.

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Function of Fimsbactin B as an Acinetobacter-Selective Antibiotic Delivery Vehicle

Abstract

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ASJC Scopus subject areas

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