Functional magnetic resonance cholangiography with Gd-EOB-DTPA: A study in healthy volunteers

Seung Wha Lee, Sang Hoon Cha, Hwan Hoon Chung, Kee Hwan Kim, Suk Keu Yeom, Bo Kyung Seo, Bo Kyung Je, Baek Hyun Kim

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)


    Purpose: To describe the patterns of bile distribution in the biliary tree, duodenum, jejunum, and stomach, and to determine the gallbladder ejection fraction (GBEF) by using functional magnetic resonance cholangiography (MRC) with gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) in healthy volunteers. Materials and Methods: Forty subjects were included in this study. After conventional MRC, pre-fatty meal MRC (PRFM) was obtained at 30, 40, 50, and 60. min after contrast agent injection. Then, post-fatty meal MRC (POFM) was obtained every 10. min for 1. h. We assessed the PRFM and POFM for opacification of contrast agent in the first- and second-order intrahepatic ducts (IHDs) and the common bile duct (CBD). Contrast agent opacification in the cystic duct was assessed, and the percentage volume of contrast agent filling in the gallbladder (GB) was calculated on PRFM. We calculated the GBEF and assessed the presence of contrast agent in the GB, duodenum, jejunum, and stomach. Results: Thirty-six (90%) subjects showed grade 3 CBD opacification (visible contrast and well-defined bile duct border) on 60-min PRFM. Thirty-four (85%) subjects showed grade 3 first-order IHD opacification on 60-min PRFM. All (100%) subjects showed cystic duct opacification of contrast agent, and the average percentage volume of contrast agent filling in the GB was 68.81%. ±. 16.84% on 60-min PRFM. The GBEF at 30-min POFM was 35.00%. ±. 18.26%. Ten (25%) subjects had no contrast agent in the stomach and small bowel on all PRFMs. Twelve (30%) subjects had contrast medium in the stomach on PRFM and/or POFM. Conclusions: Functional MRC with Gd-EOB-DTPA can allow determining the distribution of bile in the biliary tree and small intestine, as well as the GBEF.

    Original languageEnglish
    Pages (from-to)385-391
    Number of pages7
    JournalMagnetic Resonance Imaging
    Issue number4
    Publication statusPublished - 2014 May

    Bibliographical note

    Funding Information:
    Grant support: This project was supported by a grant from Bayer Schering Pharma .

    Copyright 2014 Elsevier B.V., All rights reserved.


    • Bile ducts
    • Contrast medium
    • Gastrointestinal tract
    • Gd-EOB-DTPA
    • Magnetic resonance

    ASJC Scopus subject areas

    • Biophysics
    • Biomedical Engineering
    • Radiology Nuclear Medicine and imaging


    Dive into the research topics of 'Functional magnetic resonance cholangiography with Gd-EOB-DTPA: A study in healthy volunteers'. Together they form a unique fingerprint.

    Cite this