Functional reactivity of oxanine: its biological meanings and biotechnological applications.

Seung Pil Pack; Akihiro Doi; Nagendra Kumar Kamisetty; Mitsuru Nonogawa; Tsutomu Kodaki; Keisuke Makino

doi:10.1093/nass/nrm027

Functional reactivity of oxanine: its biological meanings and biotechnological applications.

Seung Pil Pack^*
, Akihiro Doi
, Nagendra Kumar Kamisetty
, Mitsuru Nonogawa
, Tsutomu Kodaki
, Keisuke Makino

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Oxanine (Oxa), generated as one of the major products from guanine by nitrosative oxidation, has been focused as a mutagenic lesion. Here, Oxa was explored in terms of its unique property to react with - NH2 or -SH group since Oxa possesses O-acylisourea conformation in the base-ring structure. In particular, Oxa has been characterized in terms of its formation and mechanism of DNA-protein cross-link (DPC). In addition, Oxa was testified as a new carboxy-linker for activation-free covalent bonding with NH2-molecules, which can be usefully employed for the design of biotechnological or nano/biotechnological systems.

Original language	English
Pages (from-to)	53-54
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	51
DOIs	https://doi.org/10.1093/nass/nrm027
Publication status	Published - 2007
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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title = "Functional reactivity of oxanine: its biological meanings and biotechnological applications.",

abstract = "Oxanine (Oxa), generated as one of the major products from guanine by nitrosative oxidation, has been focused as a mutagenic lesion. Here, Oxa was explored in terms of its unique property to react with - NH2 or -SH group since Oxa possesses O-acylisourea conformation in the base-ring structure. In particular, Oxa has been characterized in terms of its formation and mechanism of DNA-protein cross-link (DPC). In addition, Oxa was testified as a new carboxy-linker for activation-free covalent bonding with NH2-molecules, which can be usefully employed for the design of biotechnological or nano/biotechnological systems.",

author = "Pack, \{Seung Pil\} and Akihiro Doi and Kamisetty, \{Nagendra Kumar\} and Mitsuru Nonogawa and Tsutomu Kodaki and Keisuke Makino",

year = "2007",

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T1 - Functional reactivity of oxanine

T2 - its biological meanings and biotechnological applications.

AU - Pack, Seung Pil

AU - Doi, Akihiro

AU - Kamisetty, Nagendra Kumar

AU - Nonogawa, Mitsuru

AU - Kodaki, Tsutomu

AU - Makino, Keisuke

PY - 2007

Y1 - 2007

N2 - Oxanine (Oxa), generated as one of the major products from guanine by nitrosative oxidation, has been focused as a mutagenic lesion. Here, Oxa was explored in terms of its unique property to react with - NH2 or -SH group since Oxa possesses O-acylisourea conformation in the base-ring structure. In particular, Oxa has been characterized in terms of its formation and mechanism of DNA-protein cross-link (DPC). In addition, Oxa was testified as a new carboxy-linker for activation-free covalent bonding with NH2-molecules, which can be usefully employed for the design of biotechnological or nano/biotechnological systems.

AB - Oxanine (Oxa), generated as one of the major products from guanine by nitrosative oxidation, has been focused as a mutagenic lesion. Here, Oxa was explored in terms of its unique property to react with - NH2 or -SH group since Oxa possesses O-acylisourea conformation in the base-ring structure. In particular, Oxa has been characterized in terms of its formation and mechanism of DNA-protein cross-link (DPC). In addition, Oxa was testified as a new carboxy-linker for activation-free covalent bonding with NH2-molecules, which can be usefully employed for the design of biotechnological or nano/biotechnological systems.

UR - https://www.scopus.com/pages/publications/42949116457

U2 - 10.1093/nass/nrm027

DO - 10.1093/nass/nrm027

M3 - Article

C2 - 18029582

AN - SCOPUS:42949116457

SN - 1746-8272

SP - 53

EP - 54

JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

IS - 51

ER -

Functional reactivity of oxanine: its biological meanings and biotechnological applications.

Abstract

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