TY - JOUR
T1 - Functional reactivity of oxanine
T2 - its biological meanings and biotechnological applications.
AU - Pack, Seung Pil
AU - Doi, Akihiro
AU - Kamisetty, Nagendra Kumar
AU - Nonogawa, Mitsuru
AU - Kodaki, Tsutomu
AU - Makino, Keisuke
PY - 2007
Y1 - 2007
N2 - Oxanine (Oxa), generated as one of the major products from guanine by nitrosative oxidation, has been focused as a mutagenic lesion. Here, Oxa was explored in terms of its unique property to react with - NH2 or -SH group since Oxa possesses O-acylisourea conformation in the base-ring structure. In particular, Oxa has been characterized in terms of its formation and mechanism of DNA-protein cross-link (DPC). In addition, Oxa was testified as a new carboxy-linker for activation-free covalent bonding with NH2-molecules, which can be usefully employed for the design of biotechnological or nano/biotechnological systems.
AB - Oxanine (Oxa), generated as one of the major products from guanine by nitrosative oxidation, has been focused as a mutagenic lesion. Here, Oxa was explored in terms of its unique property to react with - NH2 or -SH group since Oxa possesses O-acylisourea conformation in the base-ring structure. In particular, Oxa has been characterized in terms of its formation and mechanism of DNA-protein cross-link (DPC). In addition, Oxa was testified as a new carboxy-linker for activation-free covalent bonding with NH2-molecules, which can be usefully employed for the design of biotechnological or nano/biotechnological systems.
UR - https://www.scopus.com/pages/publications/42949116457
U2 - 10.1093/nass/nrm027
DO - 10.1093/nass/nrm027
M3 - Article
C2 - 18029582
AN - SCOPUS:42949116457
SN - 1746-8272
SP - 53
EP - 54
JO - Nucleic acids symposium series (2004)
JF - Nucleic acids symposium series (2004)
IS - 51
ER -