TY - JOUR
T1 - Functional Test Scales for Evaluating Cell-Based Therapies in Animal Models of Spinal Cord Injury
AU - Kim, Woon Ryoung
AU - Kang, Minjin
AU - Park, Heejoo
AU - Ham, Hyun Joo
AU - Lee, Hyunji
AU - Geum, Dongho
N1 - Publisher Copyright:
© 2017 Woon Ryoung Kim et al.
PY - 2017
Y1 - 2017
N2 - Recently, spinal cord researchers have focused on multifaceted approaches for the treatment of spinal cord injury (SCI). However, as there is no cure for the deficits produced by SCI, various therapeutic strategies have been examined using animal models. Due to the lack of standardized functional assessment tools for use in such models, it is important to choose a suitable animal model and precise behavioral test when evaluating the efficacy of potential SCI treatments. In the present review, we discuss recent evidence regarding functional recovery in various animal models of SCI, summarize the representative models currently used, evaluate recent cell-based therapeutic approaches, and aim to identify the most precise and appropriate scales for functional assessment in such research.
AB - Recently, spinal cord researchers have focused on multifaceted approaches for the treatment of spinal cord injury (SCI). However, as there is no cure for the deficits produced by SCI, various therapeutic strategies have been examined using animal models. Due to the lack of standardized functional assessment tools for use in such models, it is important to choose a suitable animal model and precise behavioral test when evaluating the efficacy of potential SCI treatments. In the present review, we discuss recent evidence regarding functional recovery in various animal models of SCI, summarize the representative models currently used, evaluate recent cell-based therapeutic approaches, and aim to identify the most precise and appropriate scales for functional assessment in such research.
UR - http://www.scopus.com/inward/record.url?scp=85031898720&partnerID=8YFLogxK
U2 - 10.1155/2017/5160261
DO - 10.1155/2017/5160261
M3 - Review article
AN - SCOPUS:85031898720
SN - 1687-966X
VL - 2017
JO - Stem Cells International
JF - Stem Cells International
M1 - 5160261
ER -