Functionalized exosome harboring bioactive molecules for cancer therapy

Yoon Kyoung Kim, Yoonjeong Choi, Gi Hoon Nam, In San Kim

Research output: Contribution to journalReview articlepeer-review

26 Citations (Scopus)

Abstract

Exosomes are nanosized vesicles with a lipid membrane that are secreted by most cells and play a crucial role as intermediates of intercellular communication because they carry bioactive molecules. Exosomes are promising for drug delivery of chemicals, proteins, and nucleic acids owing to their inherent properties such as excellent biocompatibility, high tumor targetability, and prolonged circulation in vivo. In this review, we cover recent approaches and advances made in the field of exosome-mediated delivery of bioactive molecules for cancer therapy and factors that affect the clinical use of exosomes. This review can be used as a guideline for further study in expanding the utility of therapeutic exosomes.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalCancer letters
Volume489
DOIs
Publication statusPublished - 2020 Oct 1

Bibliographical note

Funding Information:
This work was supported by a National Research Foundation of Korea ( NRF ) grant funded by the Korean government [ 2017R1A3B1023418 and 2018H1A2A1062948 ]; the KIST Institutional Program; the KU- KIST Graduate School of Converging Science and Technology Program. We would like to thank Editage ( www.editage.co.kr ) for English language editing.

Funding Information:
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government [2017R1A3B1023418 and 2018H1A2A1062948]; the KIST Institutional Program; the KU-KIST Graduate School of Converging Science and Technology Program. We would like to thank Editage (www.editage.co.kr) for English language editing.

Publisher Copyright:
© 2020

Keywords

  • Bioactive molecules
  • Cancer therapeutics
  • Drug delivery
  • Exosome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Functionalized exosome harboring bioactive molecules for cancer therapy'. Together they form a unique fingerprint.

Cite this