Functionalized nanoparticle probes for protein detection

Do Hyun Park, Jae Seung Lee

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


In this Review, we discuss representative studies of recent advances in the development of nanoparticle-based protein detection methods, with a focus on the properties and functionalization of nanoparticle probes, as well as their use in detection schemes. We have focused on functionalized nanoparticle probes because they offer a number of advantages over conventional assays and because their use for detecting protein targets for diagnostic purposed has been demonstrated. In this report, we discuss nanoparticle probes classified by material type (gold, silver, silica, semiconductor, carbon, and virus) and surface functionality (antibody, aptamer, and DNA), which play a critical role in enhancing the sensitivity, selectivity, and efficiency of the detection systems. In particular, the synergistic function of each component of the nanoparticle probe is emphasized in terms of specific chemical and physical properties. This research area is in its early stages with many milestones to reach before nanoparticle probes are successfully applied in the field; however, the substantial ongoing efforts of researchers underline the great promise offered by nanoparticlebased probes for future applications.

Original languageEnglish
Pages (from-to)336-345
Number of pages10
JournalElectronic Materials Letters
Issue number3
Publication statusPublished - 2015 May 30

Bibliographical note

Publisher Copyright:
© 2015, The Korean Institute of Metals and Materials and Springer Science+Business Media Dordrecht.


  • antibody
  • aptamer
  • functionalization
  • nanoparticles
  • protein detection

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials


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