Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ

Dongho Lee; Jeong Hyung Lee; Xing Fu Cai; Jin Chul Shin; Kyeong Lee; Young Soo Hong; Jung Joon Lee

doi:10.1038/ja.2005.84

Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ

Dongho Lee
, Jeong Hyung Lee
, Xing Fu Cai
, Jin Chul Shin
, Kyeong Lee
, Young Soo Hong
, Jung Joon Lee^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

A new sorbicillinoid polyketide, dihydrotrichodimerol (2), along with known trichodimerol (1), and rezishanones C (3) and D (4) were isolated by bioassay-guided fractionation from an unidentified fungal strain. Dihydrotrichodimerol (2) specifically activated peroxisome proliferator- activated receptor γ with an ED₅₀ value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors α and δ. On the other hand, compounds 1 and 2 suppressed the production of tumor necrosis factor-α and nitric oxide in LPS-stimulated RAW264.7 cells to a similar extent.

Original language	English
Pages (from-to)	615-620
Number of pages	6
Journal	Journal of Antibiotics
Volume	58
Issue number	10
DOIs	https://doi.org/10.1038/ja.2005.84
Publication status	Published - 2005 Oct
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgements The work was supported by the KRIBB Research Initiative Program and the 21C Frontier Microbial Genomics and Application Center (Grant MG05- 0303-2-0 to Y.-S.H.), the Ministry of Science and Technology, Republic of Korea. Korea Basic Science Institute is thanked for providing certain instruments used in this study.

Keywords

Nitric oxide
Peroxisome proliferator-activated receptor γ
Sorbicillinoid
Trichodimerol derivative
Tumor necrosis factor-α

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1038/ja.2005.84

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title = "Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ",

abstract = "A new sorbicillinoid polyketide, dihydrotrichodimerol (2), along with known trichodimerol (1), and rezishanones C (3) and D (4) were isolated by bioassay-guided fractionation from an unidentified fungal strain. Dihydrotrichodimerol (2) specifically activated peroxisome proliferator- activated receptor γ with an ED50 value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors α and δ. On the other hand, compounds 1 and 2 suppressed the production of tumor necrosis factor-α and nitric oxide in LPS-stimulated RAW264.7 cells to a similar extent.",

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note = "Funding Information: Acknowledgements The work was supported by the KRIBB Research Initiative Program and the 21C Frontier Microbial Genomics and Application Center (Grant MG05- 0303-2-0 to Y.-S.H.), the Ministry of Science and Technology, Republic of Korea. Korea Basic Science Institute is thanked for providing certain instruments used in this study.",

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AU - Shin, Jin Chul

AU - Lee, Kyeong

AU - Hong, Young Soo

AU - Lee, Jung Joon

N1 - Funding Information: Acknowledgements The work was supported by the KRIBB Research Initiative Program and the 21C Frontier Microbial Genomics and Application Center (Grant MG05- 0303-2-0 to Y.-S.H.), the Ministry of Science and Technology, Republic of Korea. Korea Basic Science Institute is thanked for providing certain instruments used in this study.

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AB - A new sorbicillinoid polyketide, dihydrotrichodimerol (2), along with known trichodimerol (1), and rezishanones C (3) and D (4) were isolated by bioassay-guided fractionation from an unidentified fungal strain. Dihydrotrichodimerol (2) specifically activated peroxisome proliferator- activated receptor γ with an ED50 value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors α and δ. On the other hand, compounds 1 and 2 suppressed the production of tumor necrosis factor-α and nitric oxide in LPS-stimulated RAW264.7 cells to a similar extent.

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KW - Peroxisome proliferator-activated receptor γ

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KW - Trichodimerol derivative

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Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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