Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging

Eun Kyung Lim; Byunghoon Kang; Yuna Choi; Eunji Jang; Seungmin Han; Kwangyeol Lee; Jin Suck Suh; Seungjoo Haam; Yong Min Huh

doi:10.1088/0957-4484/25/24/245103

Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging

Eun Kyung Lim, Byunghoon Kang, Yuna Choi, Eunji Jang, Seungmin Han, Kwangyeol Lee, Jin Suck Suh, Seungjoo Haam, Yong Min Huh

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy.

Original language	English
Article number	245103
Journal	Nanotechnology
Volume	25
Issue number	24
DOIs	https://doi.org/10.1088/0957-4484/25/24/245103
Publication status	Published - 2014 Jun 20

Keywords

gadolinium
high sensitivity
imaging agent
magnetic resonance image

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Mechanics of Materials
Mechanical Engineering
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1088/0957-4484/25/24/245103

Cite this

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title = "Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging",

abstract = "We developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy.",

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doi = "10.1088/0957-4484/25/24/245103",

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T1 - Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging

AU - Lim, Eun Kyung

AU - Kang, Byunghoon

AU - Choi, Yuna

AU - Jang, Eunji

AU - Han, Seungmin

AU - Lee, Kwangyeol

AU - Suh, Jin Suck

AU - Haam, Seungjoo

AU - Huh, Yong Min

PY - 2014/6/20

Y1 - 2014/6/20

N2 - We developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy.

AB - We developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy.

KW - gadolinium

KW - high sensitivity

KW - imaging agent

KW - magnetic resonance image

UR - https://www.scopus.com/pages/publications/84901651307

U2 - 10.1088/0957-4484/25/24/245103

DO - 10.1088/0957-4484/25/24/245103

M3 - Article

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AN - SCOPUS:84901651307

SN - 0957-4484

VL - 25

JO - Nanotechnology

JF - Nanotechnology

IS - 24

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ER -

Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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