Gain- and loss-of-function mutations in Zat10 enhance the tolerance of plants to abiotic stress

Ron Mittler, Yong Sig Kim, Luhua Song, Jesse Coutu, Alicia Coutu, Sultan Ciftci-Yilmaz, Hojoung Lee, Becky Stevenson, Jian Kang Zhu

Research output: Contribution to journalArticlepeer-review

353 Citations (Scopus)


C2H2-zinc finger proteins that contain the EAR repressor domain are thought to play a key role in modulating the defense response of plants to abiotic stress. Constitutive expression of the C2H2-EAR zinc finger protein Zat10 in Arabidopsis was found to elevate the expression of reactive oxygen-defense transcripts and to enhance the tolerance of plants to salinity, heat and osmotic stress. Surprisingly, knockout and RNAi mutants of Zat10 were also more tolerant to osmotic and salinity stress. Our results suggest that Zat10 plays a key role as both a positive and a negative regulator of plant defenses.

Original languageEnglish
Pages (from-to)6537-6542
Number of pages6
JournalFEBS Letters
Issue number28-29
Publication statusPublished - 2006 Dec 11
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by funding from The National Science Foundation (IBN-0420033, IBN-0420152 and NSF-0431327), National Institute of Health (R01GM059138) and The Nevada Agricultural Experimental Station (Publication number 03055517).


  • Abiotic stress
  • Arabidopsis thaliana
  • CH-zinc finger
  • EAR motif
  • Stress tolerance
  • Zat10

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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