Gamma-radiation dose-rate effects on DNA damage and toxicity in bacterial cells

Jiho Min; Chang Woo Lee; Man Bock Gu

doi:10.1007/s00411-003-0205-8

Gamma-radiation dose-rate effects on DNA damage and toxicity in bacterial cells

Jiho Min
, Chang Woo Lee
, Man Bock Gu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

In order to investigate the relationship between radiation dose-rate and bacterial DNA damage as well as general cellular toxicity, two recombinant Escherichia coli strains, DPD2794 and GC2 were used. Following gamma-ray irradiation, these bioluminescent bacteria showed quantitative stress responses in terms of DNA damage and general toxicity depending on the dose rates of energy deposition, i.e. dose-rate of radiation. In addition, an inverse relationship was found, at lower dose rates between 0.5 and 1 Gy/h and a parabolic relationship at dose rates between 0.5 and 2.6 Gy/h.

Original language	English
Pages (from-to)	189-192
Number of pages	4
Journal	Radiation and Environmental Biophysics
Volume	42
Issue number	3
DOIs	https://doi.org/10.1007/s00411-003-0205-8
Publication status	Published - 2003 Oct
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgements The authors are grateful to Dr. In Gyu Kim for the irradiation of the cells and Ms. Hyun Joo Lee for technical assistance in the preparation of the samples. This work was supported by the National Research Laboratory (2001 NRL) program of the Korea Institute of Science and Technology Evaluation and Planning (Project No. M10104000094-01J000004100). The authors are grateful for their support.

ASJC Scopus subject areas

Biophysics
Radiation
General Environmental Science

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title = "Gamma-radiation dose-rate effects on DNA damage and toxicity in bacterial cells",

abstract = "In order to investigate the relationship between radiation dose-rate and bacterial DNA damage as well as general cellular toxicity, two recombinant Escherichia coli strains, DPD2794 and GC2 were used. Following gamma-ray irradiation, these bioluminescent bacteria showed quantitative stress responses in terms of DNA damage and general toxicity depending on the dose rates of energy deposition, i.e. dose-rate of radiation. In addition, an inverse relationship was found, at lower dose rates between 0.5 and 1 Gy/h and a parabolic relationship at dose rates between 0.5 and 2.6 Gy/h.",

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note = "Funding Information: Acknowledgements The authors are grateful to Dr. In Gyu Kim for the irradiation of the cells and Ms. Hyun Joo Lee for technical assistance in the preparation of the samples. This work was supported by the National Research Laboratory (2001 NRL) program of the Korea Institute of Science and Technology Evaluation and Planning (Project No. M10104000094-01J000004100). The authors are grateful for their support.",

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doi = "10.1007/s00411-003-0205-8",

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AU - Lee, Chang Woo

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N2 - In order to investigate the relationship between radiation dose-rate and bacterial DNA damage as well as general cellular toxicity, two recombinant Escherichia coli strains, DPD2794 and GC2 were used. Following gamma-ray irradiation, these bioluminescent bacteria showed quantitative stress responses in terms of DNA damage and general toxicity depending on the dose rates of energy deposition, i.e. dose-rate of radiation. In addition, an inverse relationship was found, at lower dose rates between 0.5 and 1 Gy/h and a parabolic relationship at dose rates between 0.5 and 2.6 Gy/h.

AB - In order to investigate the relationship between radiation dose-rate and bacterial DNA damage as well as general cellular toxicity, two recombinant Escherichia coli strains, DPD2794 and GC2 were used. Following gamma-ray irradiation, these bioluminescent bacteria showed quantitative stress responses in terms of DNA damage and general toxicity depending on the dose rates of energy deposition, i.e. dose-rate of radiation. In addition, an inverse relationship was found, at lower dose rates between 0.5 and 1 Gy/h and a parabolic relationship at dose rates between 0.5 and 2.6 Gy/h.

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JF - Radiation and Environmental Biophysics

IS - 3

ER -

Gamma-radiation dose-rate effects on DNA damage and toxicity in bacterial cells

Abstract

Bibliographical note

ASJC Scopus subject areas

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