TY - JOUR
T1 - Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort
T2 - The CRESCEND study
AU - Yang, Su Jin
AU - Kim, Sun Young
AU - Stewart, Robert
AU - Kim, Jae Min
AU - Shin, Il Seon
AU - Jung, Sung Won
AU - Lee, Min-Soo
AU - Jeong, Seung Hee
AU - Jun, Tae Youn
PY - 2011/8/30
Y1 - 2011/8/30
N2 - This study aimed to determine whether men and women with depression differ in socio-demographic, treatment-related characteristics, and in their responses to treatment with antidepressants, as well as to explore differences in treatment outcomes by menopausal status. From a nationwide sample of 18 hospitals in South Korea, 723 depressive patients were recruited. After baseline evaluation, they received naturalistic clinician-determined antidepressant interventions. Assessment scales for evaluating depression (HAMD), anxiety (HAMA), global severity (CGI-s), and functioning (SOFAS) were administered at baseline and re-evaluated at 1, 2, 4, 8, and 12 weeks later. At baseline, women were older, less educated, less likely to be employed, had lower income, were more likely to be married, and had longer illness duration than men. There were no gender differences in the treatment-regime received. After adjustment for baseline status, women were more likely to achieve HAMD remission (OR = 1.51), HAMD response (OR = 1.64), and HAMA response (OR = 1.61). Women also experienced shorter times to HAMD response, HAMA response, and CGI-s remission. Postmenopausal women showed higher HAMA response with newer dual action antidepressants than premenopausal women. Women were found to have better outcomes following antidepressant treatment than men, and postmenopausal women had a better response on anxiety symptoms with newer dual action antidepressants.
AB - This study aimed to determine whether men and women with depression differ in socio-demographic, treatment-related characteristics, and in their responses to treatment with antidepressants, as well as to explore differences in treatment outcomes by menopausal status. From a nationwide sample of 18 hospitals in South Korea, 723 depressive patients were recruited. After baseline evaluation, they received naturalistic clinician-determined antidepressant interventions. Assessment scales for evaluating depression (HAMD), anxiety (HAMA), global severity (CGI-s), and functioning (SOFAS) were administered at baseline and re-evaluated at 1, 2, 4, 8, and 12 weeks later. At baseline, women were older, less educated, less likely to be employed, had lower income, were more likely to be married, and had longer illness duration than men. There were no gender differences in the treatment-regime received. After adjustment for baseline status, women were more likely to achieve HAMD remission (OR = 1.51), HAMD response (OR = 1.64), and HAMA response (OR = 1.61). Women also experienced shorter times to HAMD response, HAMA response, and CGI-s remission. Postmenopausal women showed higher HAMA response with newer dual action antidepressants than premenopausal women. Women were found to have better outcomes following antidepressant treatment than men, and postmenopausal women had a better response on anxiety symptoms with newer dual action antidepressants.
KW - Antidepressants
KW - Depression
KW - Gender differences
KW - Korea
KW - Treatment outcome
UR - http://www.scopus.com/inward/record.url?scp=79958096715&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958096715&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2010.12.027
DO - 10.1016/j.psychres.2010.12.027
M3 - Article
C2 - 21216471
AN - SCOPUS:79958096715
SN - 0165-1781
VL - 189
SP - 82
EP - 90
JO - Psychiatry Research
JF - Psychiatry Research
IS - 1
ER -