Gender Differences in Endovascular Revascularization for Peripheral Arterial Disease

Michael S. Lee; Seung Woon Rha; Seung-Kyu Han; Byoung Geol Choi; Se Yeon Choi; Pejman Mansourian; Jabar Ali; Shaopeng Xu; Harris Abdullah Ngow; Gwang No Lee; Jae Joong Lee; Ji Bak Kim; Sunki Lee; Jin Oh Na; Cheol Ung Choi; Hong Euy Lim; Jin Won Kim; Eung Ju Kim; Chang Gyu Park; Hong Seog Seo; Dong Joo Oh

Gender Differences in Endovascular Revascularization for Peripheral Arterial Disease

Michael S. Lee, Seung Woon Rha, Seung-Kyu Han, Byoung Geol Choi, Se Yeon Choi, Pejman Mansourian, Jabar Ali, Shaopeng Xu, Harris Abdullah Ngow, Gwang No Lee, Jae Joong Lee, Ji Bak Kim, Sunki Lee, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog SeoDong Joo Oh

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Objective: Peripheral arterial disease (PAD) can be treated with percutaneous transluminal angioplasty (PTA). Data comparing the outcomes of females to males with PAD who undergo PTA is limited. We compared the clinical outcomes of male and female patients with PAD who underwent PTA. Methods: In a singlecenter, prospective registry, the outcomes of 239 consecutive patients who underwent PTA for symptomatic PAD stratified by gender were analyzed. The primary endpoint was restenosis at 8 months. The secondary end points were repeat PTA, target lesion revascularization, target extremity revascularization, and amputation at a follow-up of 2 years. Results: Female patients were older (69.5±11.1 vs 65±11.6 years of age, P=.04) and had a trend toward a higher percentage of diabetic foot wound (58.1% vs 44.5%, P=.076) and PTA of tibial artery lesions (63.6% vs 53.8%, P=.064). Females had higher incidence of major hematoma (≥4 cm; 18.1% vs 8.1%, P=.033). No significant differences were observed between females and males for binary restenosis at 8 months and clinical events at 2 years. Conclusions: Female patients were older and had trends toward a higher percentage of diabetic foot wound as the initial diagnosis for PTA and PTA of tibial artery lesions. Despite having a higher incidence of major hematoma, females who underwent PTA had no significant differences in restenosis and 2-year clinical outcomes. PTA represents a viable treatment option for female patients with symptomatic PAD.

Original language	English
Pages (from-to)	117-125
Number of pages	9
Journal	Vascular Disease Management
Volume	12
Issue number	7
Publication status	Published - 2015 Jul

Keywords

Angioplasty
Endovascular therapy
Percutaneous transluminal angioplasty
Peripheral vascular disease

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Lee, M. S., Rha, S. W., Han, S-K., Choi, B. G., Choi, S. Y., Mansourian, P., Ali, J., Xu, S., Ngow, H. A., Lee, G. N., Lee, J. J., Kim, J. B., Lee, S., Na, J. O., Choi, C. U., Lim, H. E., Kim, J. W., Kim, E. J., Park, C. G., ... Oh, D. J. (2015). Gender Differences in Endovascular Revascularization for Peripheral Arterial Disease. Vascular Disease Management, 12(7), 117-125.

@article{bc77ed6938544f8fb7afb8db6d08b6ee,

title = "Gender Differences in Endovascular Revascularization for Peripheral Arterial Disease",

abstract = "Objective: Peripheral arterial disease (PAD) can be treated with percutaneous transluminal angioplasty (PTA). Data comparing the outcomes of females to males with PAD who undergo PTA is limited. We compared the clinical outcomes of male and female patients with PAD who underwent PTA. Methods: In a singlecenter, prospective registry, the outcomes of 239 consecutive patients who underwent PTA for symptomatic PAD stratified by gender were analyzed. The primary endpoint was restenosis at 8 months. The secondary end points were repeat PTA, target lesion revascularization, target extremity revascularization, and amputation at a follow-up of 2 years. Results: Female patients were older (69.5±11.1 vs 65±11.6 years of age, P=.04) and had a trend toward a higher percentage of diabetic foot wound (58.1% vs 44.5%, P=.076) and PTA of tibial artery lesions (63.6% vs 53.8%, P=.064). Females had higher incidence of major hematoma (≥4 cm; 18.1% vs 8.1%, P=.033). No significant differences were observed between females and males for binary restenosis at 8 months and clinical events at 2 years. Conclusions: Female patients were older and had trends toward a higher percentage of diabetic foot wound as the initial diagnosis for PTA and PTA of tibial artery lesions. Despite having a higher incidence of major hematoma, females who underwent PTA had no significant differences in restenosis and 2-year clinical outcomes. PTA represents a viable treatment option for female patients with symptomatic PAD.",

keywords = "Angioplasty, Endovascular therapy, Percutaneous transluminal angioplasty, Peripheral vascular disease",

author = "Lee, {Michael S.} and Rha, {Seung Woon} and Seung-Kyu Han and Choi, {Byoung Geol} and Choi, {Se Yeon} and Pejman Mansourian and Jabar Ali and Shaopeng Xu and Ngow, {Harris Abdullah} and Lee, {Gwang No} and Lee, {Jae Joong} and Kim, {Ji Bak} and Sunki Lee and Na, {Jin Oh} and Choi, {Cheol Ung} and Lim, {Hong Euy} and Kim, {Jin Won} and Kim, {Eung Ju} and Park, {Chang Gyu} and Seo, {Hong Seog} and Oh, {Dong Joo}",

year = "2015",

month = jul,

language = "English",

volume = "12",

pages = "117--125",

journal = "Vascular Disease Management",

issn = "1553-8036",

publisher = "HMP Communications",

number = "7",

}

TY - JOUR

T1 - Gender Differences in Endovascular Revascularization for Peripheral Arterial Disease

AU - Lee, Michael S.

AU - Rha, Seung Woon

AU - Han, Seung-Kyu

AU - Choi, Byoung Geol

AU - Choi, Se Yeon

AU - Mansourian, Pejman

AU - Ali, Jabar

AU - Xu, Shaopeng

AU - Ngow, Harris Abdullah

AU - Lee, Gwang No

AU - Lee, Jae Joong

AU - Kim, Ji Bak

AU - Lee, Sunki

AU - Na, Jin Oh

AU - Choi, Cheol Ung

AU - Lim, Hong Euy

AU - Kim, Jin Won

AU - Kim, Eung Ju

AU - Park, Chang Gyu

AU - Seo, Hong Seog

AU - Oh, Dong Joo

PY - 2015/7

Y1 - 2015/7

N2 - Objective: Peripheral arterial disease (PAD) can be treated with percutaneous transluminal angioplasty (PTA). Data comparing the outcomes of females to males with PAD who undergo PTA is limited. We compared the clinical outcomes of male and female patients with PAD who underwent PTA. Methods: In a singlecenter, prospective registry, the outcomes of 239 consecutive patients who underwent PTA for symptomatic PAD stratified by gender were analyzed. The primary endpoint was restenosis at 8 months. The secondary end points were repeat PTA, target lesion revascularization, target extremity revascularization, and amputation at a follow-up of 2 years. Results: Female patients were older (69.5±11.1 vs 65±11.6 years of age, P=.04) and had a trend toward a higher percentage of diabetic foot wound (58.1% vs 44.5%, P=.076) and PTA of tibial artery lesions (63.6% vs 53.8%, P=.064). Females had higher incidence of major hematoma (≥4 cm; 18.1% vs 8.1%, P=.033). No significant differences were observed between females and males for binary restenosis at 8 months and clinical events at 2 years. Conclusions: Female patients were older and had trends toward a higher percentage of diabetic foot wound as the initial diagnosis for PTA and PTA of tibial artery lesions. Despite having a higher incidence of major hematoma, females who underwent PTA had no significant differences in restenosis and 2-year clinical outcomes. PTA represents a viable treatment option for female patients with symptomatic PAD.

AB - Objective: Peripheral arterial disease (PAD) can be treated with percutaneous transluminal angioplasty (PTA). Data comparing the outcomes of females to males with PAD who undergo PTA is limited. We compared the clinical outcomes of male and female patients with PAD who underwent PTA. Methods: In a singlecenter, prospective registry, the outcomes of 239 consecutive patients who underwent PTA for symptomatic PAD stratified by gender were analyzed. The primary endpoint was restenosis at 8 months. The secondary end points were repeat PTA, target lesion revascularization, target extremity revascularization, and amputation at a follow-up of 2 years. Results: Female patients were older (69.5±11.1 vs 65±11.6 years of age, P=.04) and had a trend toward a higher percentage of diabetic foot wound (58.1% vs 44.5%, P=.076) and PTA of tibial artery lesions (63.6% vs 53.8%, P=.064). Females had higher incidence of major hematoma (≥4 cm; 18.1% vs 8.1%, P=.033). No significant differences were observed between females and males for binary restenosis at 8 months and clinical events at 2 years. Conclusions: Female patients were older and had trends toward a higher percentage of diabetic foot wound as the initial diagnosis for PTA and PTA of tibial artery lesions. Despite having a higher incidence of major hematoma, females who underwent PTA had no significant differences in restenosis and 2-year clinical outcomes. PTA represents a viable treatment option for female patients with symptomatic PAD.

KW - Angioplasty

KW - Endovascular therapy

KW - Percutaneous transluminal angioplasty

KW - Peripheral vascular disease

UR - http://www.scopus.com/inward/record.url?scp=84949449503&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84949449503

SN - 1553-8036

VL - 12

SP - 117

EP - 125

JO - Vascular Disease Management

JF - Vascular Disease Management

IS - 7

ER -

Gender Differences in Endovascular Revascularization for Peripheral Arterial Disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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