Gender differences in the clinical characteristics of psychotic depression: Results from the CRESCEND study

Seon Cheol Park, Sren Dinesen Stergaard, Jae Min Kim, Tae Youn Jun, Min-Soo Lee, Jung Bum Kim, Hyeon Woo Yim, Yong Chon Park

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)


    Objective: To test whether there are gender differences in the clinical characteristics of patients with psychotic depression (PD). Methods: Using data from the Clinical Research Center for Depression (CRESCEND) study in South Korea, we tested for potential gender differences in clinical characteristics among 53 patients with PD. The Psychotic Depression Assessment Scale (PDAS) and other psychometric scales were used to evaluate various clinical features of the study subjects. Independent t-tests were performed for normally distributed variables, Mann-Whitney U-tests for non-normally distributed variables, and χ2 tests for discrete variables. In addition, to exclude the effects of confounding variables, we carried out an analysis of covariance (ANCOVA) for the normally distributed variables and binary logistic regression analyses for discrete variables, after adjusting the effects of marital status. Results: We identified more prevalent suicidal ideation (adjusted odds ratio [aOR]=10.316, p=0.036) and hallucinatory behavior (aOR=8.332, p=0.016), as well as more severe anxiety symptoms (degrees of freedom [df]=1, F=6.123, p=0.017), and poorer social and occupational functioning (df=1, F=6.265, p=0.016) in the male patients compared to the female patients. Conclusion: Our findings suggest that in South Korean patients with PD, suicidal ideation, hallucinatory behavior, and anxiety is more pronounced among males than females. This should be taken into consideration in clinical practice.

    Original languageEnglish
    Pages (from-to)256-262
    Number of pages7
    JournalClinical Psychopharmacology and Neuroscience
    Issue number3
    Publication statusPublished - 2015 Dec 1


    • Gender
    • Hallucinatory behavior
    • Illness burden
    • Psychotic depression
    • Suicidal ideation

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Behavioral Neuroscience
    • Pharmacology (medical)


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