Gene expression profiles of rat olfactory bulb at developmental stage

Jae Hoon Cho, Hak Hyun Jung, Sang Ha K. Lee, Gi Jung Im, Jiwon Chang, Seo Jin Kim

Research output: Contribution to journalArticlepeer-review


Microarray analysis may be a useful tool to identify some candidate genes related to the development of olfactory bulbs. In the present study, gene expression profiles of olfactory bulbs from postnatal day 1 (P1) rats and postnatal day 35 (P35) rats were analyzed by oligonucleotide-microarray and expression levels of some selected genes were also confirmed by RT-PCR and in situ hybridization. 9146 genes were commonly identified in six microarray chips. Among these genes, 76 were up-regulated and 130 were down-regulated three-folds or more at P1 olfactory bulbs. Out of these 76 up-regulated genes, 24 genes were annotated based on the NCBI database of reference sequences and expression levels of these 24 genes were confirmed by RT-PCR. Among them, 2 interesting genes (neurogenic differentiation 1 and retinoid acid receptor alpha) were localized in the P1 olfactory bulb by the use of in situ hybridization technique. Our results may provide basic information to identify genes associated with functional growth of olfactory bulbs.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalJournal of Neuroscience Methods
Issue number1
Publication statusPublished - 2009 Feb 15
Externally publishedYes


  • Development
  • Gene expression
  • Olfactory bulb
  • Rat

ASJC Scopus subject areas

  • General Neuroscience


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