Gene expression profiling of aging using DNA microarrays

Richard Weindruch; Tsuyoshi Kayo; Cheol Koo Lee; Tomas A. Prolla

doi:10.1016/S0047-6374(01)00344-X

Gene expression profiling of aging using DNA microarrays

Richard Weindruch, Tsuyoshi Kayo, Cheol Koo Lee, Tomas A. Prolla

Research output: Contribution to journal › Article › peer-review

139 Citations (Scopus)

Abstract

We have previously employed high density oligonucleotide arrays representing thousands of genes to determine the gene expression profile of the aging process in skeletal muscle (gastrocnemius) and brain (cerebellum and neocortex) of male C57BL/6 mice. Specific gene expression profiles are associated with the aging process of individual organs, and caloric restriction can prevent or retard the establishment of these gene expression alterations. The use of DNA microarrays may provide a new tool to measure biological age on a tissue-specific basis and to evaluate at the molecular level the efficacy of interventions designed to retard the aging process.

Original language	English
Pages (from-to)	177-193
Number of pages	17
Journal	Mechanisms of Ageing and Development
Volume	123
Issue number	2-3
DOIs	https://doi.org/10.1016/S0047-6374(01)00344-X
Publication status	Published - 2002
Externally published	Yes

Bibliographical note

Funding Information:
Supported by NIH grants P01 AG11915 (R.W.), RO1 AG18922 (R.W.) and RO1 CA78723 (T.A.P.). T.A.P. is a recipient of the Shaw Scientist (Milwaukee Foundation), Burroughs Wellcome Young Investigator, and Basil O'Connor (March of Dimes) awards.

Keywords

Aging
Brain
Caloric restriction
DNA microarrays
Gene expression
Muscle

ASJC Scopus subject areas

Ageing
Developmental Biology

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10.1016/S0047-6374(01)00344-X

Cite this

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abstract = "We have previously employed high density oligonucleotide arrays representing thousands of genes to determine the gene expression profile of the aging process in skeletal muscle (gastrocnemius) and brain (cerebellum and neocortex) of male C57BL/6 mice. Specific gene expression profiles are associated with the aging process of individual organs, and caloric restriction can prevent or retard the establishment of these gene expression alterations. The use of DNA microarrays may provide a new tool to measure biological age on a tissue-specific basis and to evaluate at the molecular level the efficacy of interventions designed to retard the aging process.",

keywords = "Aging, Brain, Caloric restriction, DNA microarrays, Gene expression, Muscle",

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doi = "10.1016/S0047-6374(01)00344-X",

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AU - Kayo, Tsuyoshi

AU - Lee, Cheol Koo

AU - Prolla, Tomas A.

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N2 - We have previously employed high density oligonucleotide arrays representing thousands of genes to determine the gene expression profile of the aging process in skeletal muscle (gastrocnemius) and brain (cerebellum and neocortex) of male C57BL/6 mice. Specific gene expression profiles are associated with the aging process of individual organs, and caloric restriction can prevent or retard the establishment of these gene expression alterations. The use of DNA microarrays may provide a new tool to measure biological age on a tissue-specific basis and to evaluate at the molecular level the efficacy of interventions designed to retard the aging process.

AB - We have previously employed high density oligonucleotide arrays representing thousands of genes to determine the gene expression profile of the aging process in skeletal muscle (gastrocnemius) and brain (cerebellum and neocortex) of male C57BL/6 mice. Specific gene expression profiles are associated with the aging process of individual organs, and caloric restriction can prevent or retard the establishment of these gene expression alterations. The use of DNA microarrays may provide a new tool to measure biological age on a tissue-specific basis and to evaluate at the molecular level the efficacy of interventions designed to retard the aging process.

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KW - Caloric restriction

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Gene expression profiling of aging using DNA microarrays

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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