Gene expression profiling of aging using DNA microarrays

Richard Weindruch, Tsuyoshi Kayo, Cheol Koo Lee, Tomas A. Prolla

Research output: Contribution to journalArticlepeer-review

137 Citations (Scopus)

Abstract

We have previously employed high density oligonucleotide arrays representing thousands of genes to determine the gene expression profile of the aging process in skeletal muscle (gastrocnemius) and brain (cerebellum and neocortex) of male C57BL/6 mice. Specific gene expression profiles are associated with the aging process of individual organs, and caloric restriction can prevent or retard the establishment of these gene expression alterations. The use of DNA microarrays may provide a new tool to measure biological age on a tissue-specific basis and to evaluate at the molecular level the efficacy of interventions designed to retard the aging process.

Original languageEnglish
Pages (from-to)177-193
Number of pages17
JournalMechanisms of Ageing and Development
Volume123
Issue number2-3
DOIs
Publication statusPublished - 2002
Externally publishedYes

Bibliographical note

Funding Information:
Supported by NIH grants P01 AG11915 (R.W.), RO1 AG18922 (R.W.) and RO1 CA78723 (T.A.P.). T.A.P. is a recipient of the Shaw Scientist (Milwaukee Foundation), Burroughs Wellcome Young Investigator, and Basil O'Connor (March of Dimes) awards.

Keywords

  • Aging
  • Brain
  • Caloric restriction
  • DNA microarrays
  • Gene expression
  • Muscle

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology

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