Generation and reaction of cyano-substituted aryllithium compounds using microreactors

Aiichiro Nagaki, Heejin Kim, Hirotsugu Usutani, Chika Matsuo, Jun Ichi Yoshida

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)


We developed a microflow method for the generation and reactions of aryllithiums bearing a cyano group, including o-lithiobenzonitrile, m-lithiobenzonitrile and p-lithiobenzonitrile. The method was effective at much higher temperatures than are required for conventional macrobatch reactions, by virtue of rapid mixing, short residence time, and efficient temperature control. In addition, reactions of o-lithiobenzonitrile with carbonyl compounds followed by trapping of the resulting lithium alkoxides with electrophiles were achieved in an integrated microflow system.

Original languageEnglish
Pages (from-to)1212-1217
Number of pages6
JournalOrganic and Biomolecular Chemistry
Issue number5
Publication statusPublished - 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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