@article{299040067536435ea443b707fd44e585,
title = "Generation of a PXR reporter human induced pluripotent stem cell line (PXR-mCherry hiPSC) using the CRISPR/Cas9 system",
abstract = "Pregnane X receptor (PXR) is a key nuclear receptor that mediates drug metabolism and stimulates hepatocyte proliferation. However, the lack of PXR expression in human pluripotent stem cell-derived hepatocytes limits their application for drug screening and toxicity testing. Here, we generated a PXR-mCherry reporter human induced pluripotent stem cell (hiPSC) line using the CRISPR/Cas9 system. PXR-mCherry hiPSCs were pluripotent and had differentiation potential and a normal karyotype. This cell line is an important tool for identifying factors that increase PXR-mediated drug metabolism and hepatocyte proliferation.",
author = "Hyemin Kim and Kim, {Ji Woo} and Kim, {So Jin} and Choi, {Young Jun} and Kim, {Dae Sung} and Park, {Han Jin}",
note = "Funding Information: This research was supported by the Basic Science Research Program through the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (MSIP), Republic of Korea (No. NRF-2015R1C1A2A01051471). Funding Information: This research was supported by the Basic Science Research Program through the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (MSIP), Republic of Korea (No. NRF-2015R1C1A2A01051471 ). Publisher Copyright: {\textcopyright} 2017 The Authors",
year = "2018",
month = jan,
doi = "10.1016/j.scr.2017.12.001",
language = "English",
volume = "26",
pages = "72--75",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier",
}