Generation of an induced pluripotent stem cell line KUMCi001-A from CD34+ bone marrow cells of a patient with acute lymphoblastic leukemia using human placenta-derived cell conditioned medium

Seung Jin Lee; Ka Won Kang; Ji Hea Kim; Young Park; Byung Soo Kim

doi:10.1016/j.scr.2020.101913

Generation of an induced pluripotent stem cell line KUMCi001-A from CD34+ bone marrow cells of a patient with acute lymphoblastic leukemia using human placenta-derived cell conditioned medium

Seung Jin Lee, Ka Won Kang, Ji Hea Kim, Young Park, Byung Soo Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Many patients with acute lymphoblastic leukemia (ALL) show relapse post-chemotherapy. Therefore, it is important to develop a human induced pluripotent stem cell (hiPSC) line from ALL cells to verify the pathophysiology. However, the low efficiency of the established reprogramming protocol has hampered the development of ALL hiPSC lines. Our recently reported novel reprogramming method, using human placenta-derived cell conditioned medium (hPCCM), offers a relatively higher efficiency in humanized conditions. Here, we generated an hiPSC line from ALL-derived CD34+ bone marrow cells, using hPCCM for reprogramming. This hiPSC line might be a useful model for studies on ALL.

Original language	English
Article number	101913
Journal	Stem Cell Research
Volume	47
DOIs	https://doi.org/10.1016/j.scr.2020.101913
Publication status	Published - 2020 Aug

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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title = "Generation of an induced pluripotent stem cell line KUMCi001-A from CD34+ bone marrow cells of a patient with acute lymphoblastic leukemia using human placenta-derived cell conditioned medium",

abstract = "Many patients with acute lymphoblastic leukemia (ALL) show relapse post-chemotherapy. Therefore, it is important to develop a human induced pluripotent stem cell (hiPSC) line from ALL cells to verify the pathophysiology. However, the low efficiency of the established reprogramming protocol has hampered the development of ALL hiPSC lines. Our recently reported novel reprogramming method, using human placenta-derived cell conditioned medium (hPCCM), offers a relatively higher efficiency in humanized conditions. Here, we generated an hiPSC line from ALL-derived CD34+ bone marrow cells, using hPCCM for reprogramming. This hiPSC line might be a useful model for studies on ALL.",

author = "Lee, {Seung Jin} and Kang, {Ka Won} and Kim, {Ji Hea} and Young Park and Kim, {Byung Soo}",

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language = "English",

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AU - Kang, Ka Won

AU - Kim, Ji Hea

AU - Park, Young

AU - Kim, Byung Soo

PY - 2020/8

Y1 - 2020/8

N2 - Many patients with acute lymphoblastic leukemia (ALL) show relapse post-chemotherapy. Therefore, it is important to develop a human induced pluripotent stem cell (hiPSC) line from ALL cells to verify the pathophysiology. However, the low efficiency of the established reprogramming protocol has hampered the development of ALL hiPSC lines. Our recently reported novel reprogramming method, using human placenta-derived cell conditioned medium (hPCCM), offers a relatively higher efficiency in humanized conditions. Here, we generated an hiPSC line from ALL-derived CD34+ bone marrow cells, using hPCCM for reprogramming. This hiPSC line might be a useful model for studies on ALL.

AB - Many patients with acute lymphoblastic leukemia (ALL) show relapse post-chemotherapy. Therefore, it is important to develop a human induced pluripotent stem cell (hiPSC) line from ALL cells to verify the pathophysiology. However, the low efficiency of the established reprogramming protocol has hampered the development of ALL hiPSC lines. Our recently reported novel reprogramming method, using human placenta-derived cell conditioned medium (hPCCM), offers a relatively higher efficiency in humanized conditions. Here, we generated an hiPSC line from ALL-derived CD34+ bone marrow cells, using hPCCM for reprogramming. This hiPSC line might be a useful model for studies on ALL.

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Generation of an induced pluripotent stem cell line KUMCi001-A from CD34+ bone marrow cells of a patient with acute lymphoblastic leukemia using human placenta-derived cell conditioned medium

Abstract

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