Generation of cytochrome P450 enzyme-polymorphic human induced pluripotent stem cell lines with CYP2D6*10/CYP3A5*3C and CYP2D6*10/CYP2C19*2

Jaehun Lee; Gyeongmin Kim; Kyun Yoo Chi; Choongseong Han; Jong Hoon Kim

doi:10.1016/j.scr.2022.102970

Generation of cytochrome P450 enzyme-polymorphic human induced pluripotent stem cell lines with CYP2D610/CYP3A53C and CYP2D610/CYP2C192

Jaehun Lee
, Gyeongmin Kim
, Kyun Yoo Chi
, Choongseong Han
, Jong Hoon Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Cytochrome P450 (CYP) reaction phenotyping has become crucial for predicting drug reactions and side effects. Single nucleotide polymorphisms (SNPs) in CYP genes alter drug metabolism capacity and cause unexpected drug-related reactions. Here, we established two human induced pluripotent stem cell (hiPSC) lines with pharmacologically important SNPs in CYP2D6 in conjunction with CYP2C19 or CYP3A5 genes. These hiPSC lines can serve as valuable resources for expanding our understanding of the relationships between genotypes and drug reactions.

Original language	English
Article number	102970
Journal	Stem Cell Research
Volume	65
DOIs	https://doi.org/10.1016/j.scr.2022.102970
Publication status	Published - 2022 Dec

Bibliographical note

Publisher Copyright:
© 2022 The Authors

ASJC Scopus subject areas

Developmental Biology
Cell Biology

Access to Document

10.1016/j.scr.2022.102970

Cite this

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title = "Generation of cytochrome P450 enzyme-polymorphic human induced pluripotent stem cell lines with CYP2D6*10/CYP3A5*3C and CYP2D6*10/CYP2C19*2",

abstract = "Cytochrome P450 (CYP) reaction phenotyping has become crucial for predicting drug reactions and side effects. Single nucleotide polymorphisms (SNPs) in CYP genes alter drug metabolism capacity and cause unexpected drug-related reactions. Here, we established two human induced pluripotent stem cell (hiPSC) lines with pharmacologically important SNPs in CYP2D6 in conjunction with CYP2C19 or CYP3A5 genes. These hiPSC lines can serve as valuable resources for expanding our understanding of the relationships between genotypes and drug reactions.",

author = "Jaehun Lee and Gyeongmin Kim and Chi, \{Kyun Yoo\} and Choongseong Han and Kim, \{Jong Hoon\}",

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year = "2022",

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doi = "10.1016/j.scr.2022.102970",

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journal = "Stem Cell Research",

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AU - Lee, Jaehun

AU - Kim, Gyeongmin

AU - Chi, Kyun Yoo

AU - Han, Choongseong

AU - Kim, Jong Hoon

PY - 2022/12

Y1 - 2022/12

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AB - Cytochrome P450 (CYP) reaction phenotyping has become crucial for predicting drug reactions and side effects. Single nucleotide polymorphisms (SNPs) in CYP genes alter drug metabolism capacity and cause unexpected drug-related reactions. Here, we established two human induced pluripotent stem cell (hiPSC) lines with pharmacologically important SNPs in CYP2D6 in conjunction with CYP2C19 or CYP3A5 genes. These hiPSC lines can serve as valuable resources for expanding our understanding of the relationships between genotypes and drug reactions.

UR - https://www.scopus.com/pages/publications/85143283167

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DO - 10.1016/j.scr.2022.102970

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