Generation of human induced iPSC KUMi003-A from acute promyelocytic leukemia (APL) M3

Ji Hea Kim; Ka Won Kang; Byung Hyun Lee; Young Park; Byung Soo Kim

doi:10.1016/j.scr.2022.102861

Generation of human induced iPSC KUMi003-A from acute promyelocytic leukemia (APL) M3

Ji Hea Kim, Ka Won Kang, Byung Hyun Lee, Young Park, Byung Soo Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Acute promyelocytic leukemia (APL) M3 is an acute myeloid leukemia (AML) subtype and is characterized by the chromosomal translocation t(15;17)(p22;q11), which results in the fusion of the promyelocytic gene (PML) at 15q22 with the retinoic acid α-receptor gene (RARA) at 17q21. We generated an induced pluripotent stem cell line “KUMi003-A” from an APL M3 patient that is pluripotent and can differentiate into the three germ layers. This iPSC line will be useful as a disease model to investigate disease mechanisms specific to APL M3.

Original language	English
Article number	102861
Journal	Stem Cell Research
Volume	63
DOIs	https://doi.org/10.1016/j.scr.2022.102861
Publication status	Published - 2022 Aug

Bibliographical note

Funding Information:
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Byung-Soo Kim reports financial support was provided by Korea Ministry of Science and ICT.

Funding Information:
This study was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HR14C0007).

Publisher Copyright:
© 2022 The Authors

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1016/j.scr.2022.102861

Cite this

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title = "Generation of human induced iPSC KUMi003-A from acute promyelocytic leukemia (APL) M3",

abstract = "Acute promyelocytic leukemia (APL) M3 is an acute myeloid leukemia (AML) subtype and is characterized by the chromosomal translocation t(15;17)(p22;q11), which results in the fusion of the promyelocytic gene (PML) at 15q22 with the retinoic acid α-receptor gene (RARA) at 17q21. We generated an induced pluripotent stem cell line “KUMi003-A” from an APL M3 patient that is pluripotent and can differentiate into the three germ layers. This iPSC line will be useful as a disease model to investigate disease mechanisms specific to APL M3.",

author = "Kim, {Ji Hea} and Kang, {Ka Won} and Lee, {Byung Hyun} and Young Park and Kim, {Byung Soo}",

note = "Funding Information: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Byung-Soo Kim reports financial support was provided by Korea Ministry of Science and ICT. Funding Information: This study was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HR14C0007). Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

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doi = "10.1016/j.scr.2022.102861",

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journal = "Stem Cell Research",

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AB - Acute promyelocytic leukemia (APL) M3 is an acute myeloid leukemia (AML) subtype and is characterized by the chromosomal translocation t(15;17)(p22;q11), which results in the fusion of the promyelocytic gene (PML) at 15q22 with the retinoic acid α-receptor gene (RARA) at 17q21. We generated an induced pluripotent stem cell line “KUMi003-A” from an APL M3 patient that is pluripotent and can differentiate into the three germ layers. This iPSC line will be useful as a disease model to investigate disease mechanisms specific to APL M3.

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Generation of human induced iPSC KUMi003-A from acute promyelocytic leukemia (APL) M3

Abstract

Bibliographical note

ASJC Scopus subject areas

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