Abstract
X-linked Adrenoleukodystrophy (X-ALD) is a genetic disease that caused by mutations in adenosine triphosphate [ATP]-binding-cassette transporter superfamily D member 1 (ABCD1) gene. We generated an induced pluripotent stem cell (iPSC) line from a 21-year-old male X-ALD patient-derived fibroblasts by Sendai virus mediated reprogramming. Established iPSCs stably expanded while maintaining immunoreactivity for various pluripotency markers and alkaline phosphatase, as well as normal 44 + XY karyotype. Under the differentiation condition, the cells gave rise to cells of three germ layers.
Original language | English |
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Pages (from-to) | 136-138 |
Number of pages | 3 |
Journal | Stem Cell Research |
Volume | 25 |
DOIs | |
Publication status | Published - 2017 Dec |
Bibliographical note
Funding Information:This work was supported by the Bio & Medical Technology Development Program of the National Research Foundation of Korea funded by the Korea Ministry of Science, ICT & Future Planning (MSIP) NRF-2015M3A9B4071074 and School of Life Sciences and Biotechnology for BK21 PLUS, Korea University .
Publisher Copyright:
© 2017
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology