Generation of induced pluripotent stem cell (iPSC) line from a 21-year-old X-linked adrenoleukodystrophy (X-ALD) patient

Young Rang You, Daryeon Son, Phil Jun Kang, Seungkwon You, Dae Sung Kim

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    X-linked Adrenoleukodystrophy (X-ALD) is a genetic disease that caused by mutations in adenosine triphosphate [ATP]-binding-cassette transporter superfamily D member 1 (ABCD1) gene. We generated an induced pluripotent stem cell (iPSC) line from a 21-year-old male X-ALD patient-derived fibroblasts by Sendai virus mediated reprogramming. Established iPSCs stably expanded while maintaining immunoreactivity for various pluripotency markers and alkaline phosphatase, as well as normal 44 + XY karyotype. Under the differentiation condition, the cells gave rise to cells of three germ layers.

    Original languageEnglish
    Pages (from-to)136-138
    Number of pages3
    JournalStem Cell Research
    Volume25
    DOIs
    Publication statusPublished - 2017 Dec

    Bibliographical note

    Publisher Copyright:
    © 2017

    ASJC Scopus subject areas

    • Developmental Biology
    • Cell Biology

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