Generation of large pore channels for bone tissue engineering using camphene-based freeze casting

Byung Ho Yoon, Young Hag Koh, Chee Sung Park, Hyoun Ee Kim

Research output: Contribution to journalArticlepeer-review

106 Citations (Scopus)


The present study reports an innovative way to produce large pore channels with a size >100 μm for applications in bone tissue engineering using the camphene-based freeze casting method, and using an unusually high freezing temperature, which is close to the solidification temperature of the slurry, in order to allow the formation of excessively overgrown camphene dendrites due to the extremely low solidification velocity. To accomplish this, hydroxyapatite (HA)/slurries with various solid loadings (10, 15, and 20 vol%) were frozen at 35°C for 20 h. The frozen samples were freeze dried and sintered at 1250°C for 3 h. All of the fabricated samples showed highly porous structures with large pore channels >100 μm in size and dense HA walls without any noticeable defects, such as cracks or pores. As the initial solid loading was increased from 10 to 20 vol%, the porosity of the sample decreased linearly from 76% to 55%, while the pore channels became narrower. However, the compressive strength was remarkably improved from 2.5 to 16.7 MPa.

Original languageEnglish
Pages (from-to)1744-1752
Number of pages9
JournalJournal of the American Ceramic Society
Issue number6
Publication statusPublished - 2007 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry


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