Generation of the induced pluripotent stem cell line KUMi001-A carrying the Philadelphia chromosome from a chronic myeloid leukemia patient

Ji Hea Kim; Ka Won Kang; Byung Hyun Lee; Young Park; Byung Soo Kim

doi:10.1016/j.scr.2021.102464

Generation of the induced pluripotent stem cell line KUMi001-A carrying the Philadelphia chromosome from a chronic myeloid leukemia patient

Ji Hea Kim, Ka Won Kang, Byung Hyun Lee, Young Park, Byung Soo Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Chronic myeloid leukemia (CML) is caused by the BCR-ABL fusion protein, which dysregulates tyrosine kinase activity. In this study, we generated induced pluripotent stem cells (iPSCs) carrying the Philadelphia chromosome from a CML patient with the BCR-ABL fusion protein. CML iPSCs were positive for pluripotency markers and had the ability to differentiate into the three germ layers. This iPSC cell line could be useful for studying CML pathogenesis as well as for drug development to treat CML.

Original language	English
Article number	102464
Journal	Stem Cell Research
Volume	55
DOIs	https://doi.org/10.1016/j.scr.2021.102464
Publication status	Published - 2021 Aug

Keywords

Chronic myeloid leukemia
Induced pluripotent stem cells
Philadelphia chromosome

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1016/j.scr.2021.102464

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title = "Generation of the induced pluripotent stem cell line KUMi001-A carrying the Philadelphia chromosome from a chronic myeloid leukemia patient",

abstract = "Chronic myeloid leukemia (CML) is caused by the BCR-ABL fusion protein, which dysregulates tyrosine kinase activity. In this study, we generated induced pluripotent stem cells (iPSCs) carrying the Philadelphia chromosome from a CML patient with the BCR-ABL fusion protein. CML iPSCs were positive for pluripotency markers and had the ability to differentiate into the three germ layers. This iPSC cell line could be useful for studying CML pathogenesis as well as for drug development to treat CML.",

keywords = "Chronic myeloid leukemia, Induced pluripotent stem cells, Philadelphia chromosome",

author = "Kim, {Ji Hea} and Kang, {Ka Won} and Lee, {Byung Hyun} and Young Park and Kim, {Byung Soo}",

note = "Funding Information: This study was supported by the Bio & Medical Technology Development Program of the National Research Foundation, funded by the Ministry of Science and ICT (2017M3A9C8060403). Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

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journal = "Stem Cell Research",

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T1 - Generation of the induced pluripotent stem cell line KUMi001-A carrying the Philadelphia chromosome from a chronic myeloid leukemia patient

AU - Kim, Ji Hea

AU - Kang, Ka Won

AU - Lee, Byung Hyun

AU - Park, Young

AU - Kim, Byung Soo

N1 - Funding Information: This study was supported by the Bio & Medical Technology Development Program of the National Research Foundation, funded by the Ministry of Science and ICT (2017M3A9C8060403). Publisher Copyright: © 2021 The Author(s)

PY - 2021/8

Y1 - 2021/8

N2 - Chronic myeloid leukemia (CML) is caused by the BCR-ABL fusion protein, which dysregulates tyrosine kinase activity. In this study, we generated induced pluripotent stem cells (iPSCs) carrying the Philadelphia chromosome from a CML patient with the BCR-ABL fusion protein. CML iPSCs were positive for pluripotency markers and had the ability to differentiate into the three germ layers. This iPSC cell line could be useful for studying CML pathogenesis as well as for drug development to treat CML.

AB - Chronic myeloid leukemia (CML) is caused by the BCR-ABL fusion protein, which dysregulates tyrosine kinase activity. In this study, we generated induced pluripotent stem cells (iPSCs) carrying the Philadelphia chromosome from a CML patient with the BCR-ABL fusion protein. CML iPSCs were positive for pluripotency markers and had the ability to differentiate into the three germ layers. This iPSC cell line could be useful for studying CML pathogenesis as well as for drug development to treat CML.

KW - Chronic myeloid leukemia

KW - Induced pluripotent stem cells

KW - Philadelphia chromosome

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SN - 1873-5061

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JO - Stem Cell Research

JF - Stem Cell Research

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ER -

Generation of the induced pluripotent stem cell line KUMi001-A carrying the Philadelphia chromosome from a chronic myeloid leukemia patient

Abstract

Keywords

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