Generation of two induced pluripotent stem cell (iPSC) lines from X-linked adrenoleukodystrophy (X-ALD) patients with adrenomyeloneuropathy (AMN)

Daryeon Son; Zhejiu Quan; Phil Jun Kang; Gyuman Park; Hoon Chul Kang; Seungkwon You

doi:10.1016/j.scr.2017.10.003

Generation of two induced pluripotent stem cell (iPSC) lines from X-linked adrenoleukodystrophy (X-ALD) patients with adrenomyeloneuropathy (AMN)

Daryeon Son, Zhejiu Quan, Phil Jun Kang, Gyuman Park, Hoon Chul Kang^*, Seungkwon You

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by a mutation in the ATP-binding cassette transporter subfamily D member 1 (ABCD1) gene. We generated two induced pluripotent stem cell (iPSC) lines from X-ALD patients with adrenomyeloneuropathy (AMN) by Sendai virus containing OCT4, SOX2, KLF4 and c-MYC. Established iPSC lines expressed various pluripotency markers, had differentiation potential of three germ layers in vitro, had normal karyotype and retained ABCD1 mutation.

Original language	English
Pages (from-to)	46-49
Number of pages	4
Journal	Stem Cell Research
Volume	25
DOIs	https://doi.org/10.1016/j.scr.2017.10.003
Publication status	Published - 2017 Dec

Bibliographical note

Funding Information:
This work was supported by the Bio & Medical Technology Development Program of the National Research Foundation of Korea funded by the Korea Ministry of Science, ICT & Future Planning (MSIP) NRF-2015M3A9B4071074 , a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI15C2944 ), a Institute of Animal Molecular Biotechnology Grant and School of Life Sciences and Biotechnology for BK21 PLUS, Korea University. Appendix A

Publisher Copyright:
© 2017 The Authors

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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title = "Generation of two induced pluripotent stem cell (iPSC) lines from X-linked adrenoleukodystrophy (X-ALD) patients with adrenomyeloneuropathy (AMN)",

abstract = "X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by a mutation in the ATP-binding cassette transporter subfamily D member 1 (ABCD1) gene. We generated two induced pluripotent stem cell (iPSC) lines from X-ALD patients with adrenomyeloneuropathy (AMN) by Sendai virus containing OCT4, SOX2, KLF4 and c-MYC. Established iPSC lines expressed various pluripotency markers, had differentiation potential of three germ layers in vitro, had normal karyotype and retained ABCD1 mutation.",

author = "Daryeon Son and Zhejiu Quan and Kang, \{Phil Jun\} and Gyuman Park and Kang, \{Hoon Chul\} and Seungkwon You",

note = "Funding Information: This work was supported by the Bio \& Medical Technology Development Program of the National Research Foundation of Korea funded by the Korea Ministry of Science, ICT \& Future Planning (MSIP) NRF-2015M3A9B4071074 , a grant of the Korea Health Technology R\&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health \& Welfare, Republic of Korea (grant number: HI15C2944 ), a Institute of Animal Molecular Biotechnology Grant and School of Life Sciences and Biotechnology for BK21 PLUS, Korea University. Appendix A Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

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doi = "10.1016/j.scr.2017.10.003",

language = "English",

volume = "25",

pages = "46--49",

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AU - Son, Daryeon

AU - Quan, Zhejiu

AU - Kang, Phil Jun

AU - Park, Gyuman

AU - Kang, Hoon Chul

AU - You, Seungkwon

N1 - Funding Information: This work was supported by the Bio & Medical Technology Development Program of the National Research Foundation of Korea funded by the Korea Ministry of Science, ICT & Future Planning (MSIP) NRF-2015M3A9B4071074 , a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI15C2944 ), a Institute of Animal Molecular Biotechnology Grant and School of Life Sciences and Biotechnology for BK21 PLUS, Korea University. Appendix A Publisher Copyright: © 2017 The Authors

PY - 2017/12

Y1 - 2017/12

N2 - X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by a mutation in the ATP-binding cassette transporter subfamily D member 1 (ABCD1) gene. We generated two induced pluripotent stem cell (iPSC) lines from X-ALD patients with adrenomyeloneuropathy (AMN) by Sendai virus containing OCT4, SOX2, KLF4 and c-MYC. Established iPSC lines expressed various pluripotency markers, had differentiation potential of three germ layers in vitro, had normal karyotype and retained ABCD1 mutation.

AB - X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by a mutation in the ATP-binding cassette transporter subfamily D member 1 (ABCD1) gene. We generated two induced pluripotent stem cell (iPSC) lines from X-ALD patients with adrenomyeloneuropathy (AMN) by Sendai virus containing OCT4, SOX2, KLF4 and c-MYC. Established iPSC lines expressed various pluripotency markers, had differentiation potential of three germ layers in vitro, had normal karyotype and retained ABCD1 mutation.

UR - https://www.scopus.com/pages/publications/85031775761

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SN - 1873-5061

VL - 25

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JO - Stem Cell Research

JF - Stem Cell Research

ER -

Generation of two induced pluripotent stem cell (iPSC) lines from X-linked adrenoleukodystrophy (X-ALD) patients with adrenomyeloneuropathy (AMN)

Abstract

Bibliographical note

ASJC Scopus subject areas

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