Genetic characterization of haemagglutinin 1 domain of influenza B viruses isolated in Korea during 1988-1999

Gu Choul Shin, Byoung Kuk Na, Joo Yeon Lee, Jung Bae Ahn, Jong Won Park, Jin Soo Lee, Jee Hee Kim, Woo Joo Kim, Chun Kang

    Research output: Contribution to journalArticlepeer-review


    Although Korean influenza virus isolates have been genetically associated with the vaccine strains of the corresponding year, influenza B viruses have prevailed almost every year in Korea during the past decades. We have analyzed the genetic characteristics and evolutionary patterns of the haemagglutinin (HA) 1 domains of influenza B viruses isolated during 1988-1999 using direct RT-PCR and sequencing. Phylogenetic analysis of influenza B viruses isolated in Korea indicated that antigenically and genetically distinguishable strains of the lineage II and lineage III variants had been cocirculated. Variants prevailed in early 1990s are represented in 1996/97 and 1998/99 and some different variants have been cocirculated geographically and prevailed concurrently in Korea. All HA1s of Korean isolates have amino acid substitutions mainly in the region between position 124 and 310, which was previously proposed an immunodominant region. Insertion-deletion patterns of the HA gene revealed that Korean influenza B viruses were evolved from Lee40 with different manner between lineage II and III viruses. Lineage III viruses were also divided into two groups as conserved group and inserted group, in relation to Lee40. But lineage II viruses had evolved with directional pattern. Antigenic index proposed that influenza B isolates prevailed since 1996/97 seasons might had emerged from the antigenic variants of a Seo1697-like virus and that new variants might appear from the lineage II viruses resulting in persistent prevalence in Korea.

    Original languageEnglish
    Pages (from-to)357-369
    Number of pages13
    JournalJournal of Bacteriology and Virology
    Issue number4
    Publication statusPublished - 2003


    • Genetic characterization
    • Haemagglutinin
    • Influenza B virus

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Virology


    Dive into the research topics of 'Genetic characterization of haemagglutinin 1 domain of influenza B viruses isolated in Korea during 1988-1999'. Together they form a unique fingerprint.

    Cite this