Genetic diversity of Apodemus agrarius-Borne Hantaan virus in Korea

J. W. Song; L. J. Baek; S. H. Kim; E. Y. Kho; J. H. Kim; R. Yanagihara; K. J. Song

doi:10.1023/A:1008199800011

Genetic diversity of Apodemus agrarius-Borne Hantaan virus in Korea

J. W. Song, L. J. Baek, S. H. Kim, E. Y. Kho, J. H. Kim, R. Yanagihara, K. J. Song

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Hantaan (HTN) virus, the etiologic agent of clinically severe hemorrhagic fever with renal syndrome (HFRS), was first isolated in 1976 from lung tissues of striped field mice (Apodemus agrarius) captured in Songnae-ri, Kyungki-do, Korea. To clarify the genetic diversity and phylogenetic relationship among Korean strains of HTN virus, viral sequences of the partial S and M segments were amplified from lung tissues of 24 seropositive striped field mice captured between 1989 and 1998 at 11 sites in South Korea. The 771-nucleotide (nt) S segment sequences (coordinates 432 to 1202) of HTN virus strains from Yangju-kun differed by 10 to 40nt (1.3 to 5.2%) from virus strains from Pocheon-kun, Songnae-ri and Nonsan-kun. Similar degrees of genetic variation were found in the G1 and G2 glycoprotein-encoding M segment. Phylogenetic trees, based on the partial S and M segments and generated by the maximum parsimony and neighbor-joining methods, demonstrated that virus strains from various geographic regions in South Korea showed a tendency to form two phylogenetic subgroups and were evolutionarily distinct from HTN virus strains from the People's Republic of China.

Original language	English
Pages (from-to)	227-232
Number of pages	6
Journal	Virus Genes
Volume	21
Issue number	3
DOIs	https://doi.org/10.1023/A:1008199800011
Publication status	Published - 2000

Bibliographical note

Funding Information:
This work was supported in part by grants from the Health Technology Planning & Evaluation Board, Ministry of Health & Welfare, Korea (grant HMP-98-M-2-0033) and the Research Centers in Minority Institutions Program of the National Center for Research Resources, National Institutes of Health (G12RR/AI-03061).

Keywords

Genetic diversity
Hantaan virus
Hantavirus
RT-PCR

ASJC Scopus subject areas

Molecular Biology
Genetics
Virology

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10.1023/A:1008199800011

Cite this

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title = "Genetic diversity of Apodemus agrarius-Borne Hantaan virus in Korea",

abstract = "Hantaan (HTN) virus, the etiologic agent of clinically severe hemorrhagic fever with renal syndrome (HFRS), was first isolated in 1976 from lung tissues of striped field mice (Apodemus agrarius) captured in Songnae-ri, Kyungki-do, Korea. To clarify the genetic diversity and phylogenetic relationship among Korean strains of HTN virus, viral sequences of the partial S and M segments were amplified from lung tissues of 24 seropositive striped field mice captured between 1989 and 1998 at 11 sites in South Korea. The 771-nucleotide (nt) S segment sequences (coordinates 432 to 1202) of HTN virus strains from Yangju-kun differed by 10 to 40nt (1.3 to 5.2%) from virus strains from Pocheon-kun, Songnae-ri and Nonsan-kun. Similar degrees of genetic variation were found in the G1 and G2 glycoprotein-encoding M segment. Phylogenetic trees, based on the partial S and M segments and generated by the maximum parsimony and neighbor-joining methods, demonstrated that virus strains from various geographic regions in South Korea showed a tendency to form two phylogenetic subgroups and were evolutionarily distinct from HTN virus strains from the People's Republic of China.",

keywords = "Genetic diversity, Hantaan virus, Hantavirus, RT-PCR",

author = "Song, {J. W.} and Baek, {L. J.} and Kim, {S. H.} and Kho, {E. Y.} and Kim, {J. H.} and R. Yanagihara and Song, {K. J.}",

note = "Funding Information: This work was supported in part by grants from the Health Technology Planning & Evaluation Board, Ministry of Health & Welfare, Korea (grant HMP-98-M-2-0033) and the Research Centers in Minority Institutions Program of the National Center for Research Resources, National Institutes of Health (G12RR/AI-03061).",

year = "2000",

doi = "10.1023/A:1008199800011",

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AU - Song, J. W.

AU - Baek, L. J.

AU - Kim, S. H.

AU - Kho, E. Y.

AU - Kim, J. H.

AU - Yanagihara, R.

AU - Song, K. J.

N1 - Funding Information: This work was supported in part by grants from the Health Technology Planning & Evaluation Board, Ministry of Health & Welfare, Korea (grant HMP-98-M-2-0033) and the Research Centers in Minority Institutions Program of the National Center for Research Resources, National Institutes of Health (G12RR/AI-03061).

PY - 2000

Y1 - 2000

N2 - Hantaan (HTN) virus, the etiologic agent of clinically severe hemorrhagic fever with renal syndrome (HFRS), was first isolated in 1976 from lung tissues of striped field mice (Apodemus agrarius) captured in Songnae-ri, Kyungki-do, Korea. To clarify the genetic diversity and phylogenetic relationship among Korean strains of HTN virus, viral sequences of the partial S and M segments were amplified from lung tissues of 24 seropositive striped field mice captured between 1989 and 1998 at 11 sites in South Korea. The 771-nucleotide (nt) S segment sequences (coordinates 432 to 1202) of HTN virus strains from Yangju-kun differed by 10 to 40nt (1.3 to 5.2%) from virus strains from Pocheon-kun, Songnae-ri and Nonsan-kun. Similar degrees of genetic variation were found in the G1 and G2 glycoprotein-encoding M segment. Phylogenetic trees, based on the partial S and M segments and generated by the maximum parsimony and neighbor-joining methods, demonstrated that virus strains from various geographic regions in South Korea showed a tendency to form two phylogenetic subgroups and were evolutionarily distinct from HTN virus strains from the People's Republic of China.

AB - Hantaan (HTN) virus, the etiologic agent of clinically severe hemorrhagic fever with renal syndrome (HFRS), was first isolated in 1976 from lung tissues of striped field mice (Apodemus agrarius) captured in Songnae-ri, Kyungki-do, Korea. To clarify the genetic diversity and phylogenetic relationship among Korean strains of HTN virus, viral sequences of the partial S and M segments were amplified from lung tissues of 24 seropositive striped field mice captured between 1989 and 1998 at 11 sites in South Korea. The 771-nucleotide (nt) S segment sequences (coordinates 432 to 1202) of HTN virus strains from Yangju-kun differed by 10 to 40nt (1.3 to 5.2%) from virus strains from Pocheon-kun, Songnae-ri and Nonsan-kun. Similar degrees of genetic variation were found in the G1 and G2 glycoprotein-encoding M segment. Phylogenetic trees, based on the partial S and M segments and generated by the maximum parsimony and neighbor-joining methods, demonstrated that virus strains from various geographic regions in South Korea showed a tendency to form two phylogenetic subgroups and were evolutionarily distinct from HTN virus strains from the People's Republic of China.

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KW - Hantavirus

KW - RT-PCR

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Genetic diversity of Apodemus agrarius-Borne Hantaan virus in Korea

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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