Genetic polymorphism of Plasmodium vivax msp1p, a paralog of merozoite surface protein 1, from worldwide isolates

Yue Wang, Osamu Kaneko, Jetsumon Sattabongkot, Jun Hu Chen, Feng Lu, Jong Yil Chai, Satoru Takeo, Takafumi Tsuboi, Francisco J. Ayala, Yong Chen, Chae Seung Lim, Eun Taek Han

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    Plasmodium vivax msp1p, a paralog of the candidate vaccine antigen P. vivax merozoite surface protein 1, possesses a signal peptide at its N-terminus and two epidermal growth factor-like domains at its C-terminus with a glycosylphosphatidylinositol attachment site. The msp1p gene locus may have originated by a duplication of the msp1 gene locus in a common ancestor of the analyzed Plasmodium species and lost from P. yoelii, P. berghei, and P. falciparum during their evolutionary history. Full-length sequences of the msp1p gene were generally highly conserved; they had a few amino acid substitutions, one highly polymorphic E/Q-rich region, and a single-to-triple hepta-peptide repeat motif. Twenty-one distinguishable allelic types (A1-A21) of the E/Q-rich region were identified from worldwide isolates. Among them, four types were detected in isolates from South Korea. The length polymorphism of the E/Q-rich region might be useful as a genetic marker for population structure studies in malaria-endemic areas.

    Original languageEnglish
    Pages (from-to)292-297
    Number of pages6
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Volume84
    Issue number2
    DOIs
    Publication statusPublished - 2011 Feb

    ASJC Scopus subject areas

    • Parasitology
    • Virology
    • Infectious Diseases

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