Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism

Ihn Geun Choi; Baik Seok Kee; Hyun Gyun Son; Byung Joo Ham; Byung Hwan Yang; Seok Hyeon Kim; Jun Suk Lee; Bong Ki Son; Byeong Yong Lee; Sang Yeol Lee; Young Gyu Chai; Hyoung Doo Shin

doi:10.1016/j.euroneuro.2005.07.006

Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism

Ihn Geun Choi
, Baik Seok Kee^*
, Hyun Gyun Son
, Byung Joo Ham
, Byung Hwan Yang
, Seok Hyeon Kim
, Jun Suk Lee
, Bong Ki Son
, Byeong Yong Lee
, Sang Yeol Lee
, Young Gyu Chai
, Hyoung Doo Shin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), serotonin transporter (5-HTT) and dopamine transporter (DAT1). There were significant differences in genotype frequencies of ADH2 C992G and A13543G SNPs between alcoholic patients with family history of alcohol dependence (familial) and alcoholic patients without family history (non-familial). Genotype and allele frequencies of ALDH2 G1951A SNP in familial or non-familial alcoholic patients differ from normal controls. Neither 5-HTTLPR L/S nor DAT1 G2319A SNP genotypes nor alleles discriminated alcoholic patients from normal controls. These findings suggest that the genetic characteristics of alcohol metabolism in non-familial alcoholics fall between non-alcoholism and familial alcoholics.

Original language	English
Pages (from-to)	123-128
Number of pages	6
Journal	European Neuropsychopharmacology
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.euroneuro.2005.07.006
Publication status	Published - 2006 Feb
Externally published	Yes

Bibliographical note

Funding Information:
Presented in part and awarded (ECNP Travel Award 2003) at the 16th ECNP Congress, Prague, Czech Republic, September 20–24, 2003. This research was supported by the Chung-Ang University Research Grants in 2003, and a grant of the Biomedical Brain Research Center Grant, Ministry of Health and Welfare, Republic of Korea (01-PJ8-PG6-01NE01-0003).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alcohol dehydrogenase 2
Alcoholism
Aldehyde dehydrogenase 2
Dopamine transporter
Family history
Serotonin transporter

ASJC Scopus subject areas

Pharmacology
Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry
Pharmacology (medical)

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10.1016/j.euroneuro.2005.07.006

Cite this

Choi, I. G., Kee, B. S., Son, H. G., Ham, B. J., Yang, B. H., Kim, S. H., Lee, J. S., Son, B. K., Lee, B. Y., Lee, S. Y., Chai, Y. G., & Shin, H. D. (2006). Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism. European Neuropsychopharmacology, 16(2), 123-128. https://doi.org/10.1016/j.euroneuro.2005.07.006

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title = "Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism",

abstract = "One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), serotonin transporter (5-HTT) and dopamine transporter (DAT1). There were significant differences in genotype frequencies of ADH2 C992G and A13543G SNPs between alcoholic patients with family history of alcohol dependence (familial) and alcoholic patients without family history (non-familial). Genotype and allele frequencies of ALDH2 G1951A SNP in familial or non-familial alcoholic patients differ from normal controls. Neither 5-HTTLPR L/S nor DAT1 G2319A SNP genotypes nor alleles discriminated alcoholic patients from normal controls. These findings suggest that the genetic characteristics of alcohol metabolism in non-familial alcoholics fall between non-alcoholism and familial alcoholics.",

keywords = "Alcohol dehydrogenase 2, Alcoholism, Aldehyde dehydrogenase 2, Dopamine transporter, Family history, Serotonin transporter",

author = "Choi, \{Ihn Geun\} and Kee, \{Baik Seok\} and Son, \{Hyun Gyun\} and Ham, \{Byung Joo\} and Yang, \{Byung Hwan\} and Kim, \{Seok Hyeon\} and Lee, \{Jun Suk\} and Son, \{Bong Ki\} and Lee, \{Byeong Yong\} and Lee, \{Sang Yeol\} and Chai, \{Young Gyu\} and Shin, \{Hyoung Doo\}",

note = "Funding Information: Presented in part and awarded (ECNP Travel Award 2003) at the 16th ECNP Congress, Prague, Czech Republic, September 20–24, 2003. This research was supported by the Chung-Ang University Research Grants in 2003, and a grant of the Biomedical Brain Research Center Grant, Ministry of Health and Welfare, Republic of Korea (01-PJ8-PG6-01NE01-0003).",

year = "2006",

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doi = "10.1016/j.euroneuro.2005.07.006",

language = "English",

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AU - Son, Hyun Gyun

AU - Ham, Byung Joo

AU - Yang, Byung Hwan

AU - Kim, Seok Hyeon

AU - Lee, Jun Suk

AU - Son, Bong Ki

AU - Lee, Byeong Yong

AU - Lee, Sang Yeol

AU - Chai, Young Gyu

AU - Shin, Hyoung Doo

N1 - Funding Information: Presented in part and awarded (ECNP Travel Award 2003) at the 16th ECNP Congress, Prague, Czech Republic, September 20–24, 2003. This research was supported by the Chung-Ang University Research Grants in 2003, and a grant of the Biomedical Brain Research Center Grant, Ministry of Health and Welfare, Republic of Korea (01-PJ8-PG6-01NE01-0003).

PY - 2006/2

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N2 - One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), serotonin transporter (5-HTT) and dopamine transporter (DAT1). There were significant differences in genotype frequencies of ADH2 C992G and A13543G SNPs between alcoholic patients with family history of alcohol dependence (familial) and alcoholic patients without family history (non-familial). Genotype and allele frequencies of ALDH2 G1951A SNP in familial or non-familial alcoholic patients differ from normal controls. Neither 5-HTTLPR L/S nor DAT1 G2319A SNP genotypes nor alleles discriminated alcoholic patients from normal controls. These findings suggest that the genetic characteristics of alcohol metabolism in non-familial alcoholics fall between non-alcoholism and familial alcoholics.

AB - One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), serotonin transporter (5-HTT) and dopamine transporter (DAT1). There were significant differences in genotype frequencies of ADH2 C992G and A13543G SNPs between alcoholic patients with family history of alcohol dependence (familial) and alcoholic patients without family history (non-familial). Genotype and allele frequencies of ALDH2 G1951A SNP in familial or non-familial alcoholic patients differ from normal controls. Neither 5-HTTLPR L/S nor DAT1 G2319A SNP genotypes nor alleles discriminated alcoholic patients from normal controls. These findings suggest that the genetic characteristics of alcohol metabolism in non-familial alcoholics fall between non-alcoholism and familial alcoholics.

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KW - Aldehyde dehydrogenase 2

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KW - Family history

KW - Serotonin transporter

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Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

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