Geometrical effects of nanowire electrodes for amperometric enzyme biosensors

Sangwook Kim, Junhong Na, Seung Koo Lee, Min Jung Song, Pilsoo Kang, Junghwan Huh, Dae Soon Lim, Gyu Tae Kim

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Enzymatic biosensor reactions follow the Michaelis-Menten kinetics, coupled with diffusion. The diffusion reaction processes for amperometric enzyme biosensors have been simulated to explore the geometrical effects of nanowire array electrodes (NWAEs) and nanowire array stack electrodes (NWASEs) from the viewpoint of enhanced mass transport and increased reaction surface area in two limiting cases. For practical analysis considering sensor fabrication, most samples are assumed to have the same unit square (1 cm × 1 cm) footprint. In the reaction-controlled case, the surface area increment improves the sensitivity regardless of electrode geometry. However, in the diffusion-controlled case, well-controlled NWAE or NWASE geometries as well as the increased surface area improve the sensitivity when the peak current at an early stage of the reaction is measured. Peak current engineering by adjusting the geometric parameters of NWAEs and NWASEs will result in a highly sensitive amperometric enzyme biosensor in the diffusion-controlled case. In contrast to previous micro- and nanoelectrode array studies, we investigated NWASEs representing entangled nanowire network electrodes, and report significant improvements in both limiting cases.

Original languageEnglish
Pages (from-to)222-229
Number of pages8
JournalSensors and Actuators, B: Chemical
Volume183
DOIs
Publication statusPublished - 2013

Bibliographical note

Funding Information:
We thankfully acknowledge the financial support from the Ministry of Education, Science and Technology, provided to the project EDISON (EDucation-research Integration through Simulation On the Net, Grant No.: 2012035308). This study was also supported by Korea University Grant . The authors would like to thank Ho-Kyun Jang for 3D graphics, and Sung-Hee Lee for secretarial support.

Keywords

  • Amperometric enzyme biosensor Nanowire array electrode Nanowire array stack electrode Geometry Mass transport Surface area

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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