Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways

Su Hwa Kim, Hyun Cheol Bae, Eun Jung Park, Chae Ryun Lee, Byung Joo Kim, Sanghoon Lee, Hyun Ho Park, Sung Joon Kim, Insuk So, Tae Woo Kim, Ju Hong Jeon

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)

Abstract

The progression of prostate cancer is associated with escape from cell cycle arrest and apoptosis under androgen-depleted conditions. Here, we found that geraniol, a naturally occurring monoterpene, induces cell cycle arrest and apoptosis in cultured cells and tumor grafted mice using PC-3 prostate cancer cells. Geraniol modulated the expression of various cell cycle regulators and Bcl-2 family proteins in PC-3 cells in vitro and in vivo. Furthermore, we showed that the combination of sub-optimal doses of geraniol and docetaxel noticeably suppresses prostate cancer growth in cultured cells and tumor xenograft mice. Therefore, our findings provide insight into unraveling the mechanisms underlying escape from cell cycle arrest and apoptosis and developing therapeutic strategies against prostate cancer.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalBiochemical and biophysical research communications
Volume407
Issue number1
DOIs
Publication statusPublished - 2011 Apr 1

Bibliographical note

Funding Information:
Human TRPA8 construct was kindly provided by Dr. Barbara A. Niemeyer (University of Saarland). This study was supported by a grant of the Korea Health 21R&D project, Ministry of Health, Welfare and Family Affairs, Republic of Korea ( A090388 ).

Keywords

  • Anticancer activity
  • Apoptosis
  • Cell cycle
  • Chemosensitivity
  • Geraniol
  • Prostate cancer

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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