The progression of prostate cancer is associated with escape from cell cycle arrest and apoptosis under androgen-depleted conditions. Here, we found that geraniol, a naturally occurring monoterpene, induces cell cycle arrest and apoptosis in cultured cells and tumor grafted mice using PC-3 prostate cancer cells. Geraniol modulated the expression of various cell cycle regulators and Bcl-2 family proteins in PC-3 cells in vitro and in vivo. Furthermore, we showed that the combination of sub-optimal doses of geraniol and docetaxel noticeably suppresses prostate cancer growth in cultured cells and tumor xenograft mice. Therefore, our findings provide insight into unraveling the mechanisms underlying escape from cell cycle arrest and apoptosis and developing therapeutic strategies against prostate cancer.
|Number of pages
|Biochemical and biophysical research communications
|Published - 2011 Apr 1
Bibliographical noteFunding Information:
Human TRPA8 construct was kindly provided by Dr. Barbara A. Niemeyer (University of Saarland). This study was supported by a grant of the Korea Health 21R&D project, Ministry of Health, Welfare and Family Affairs, Republic of Korea ( A090388 ).
- Anticancer activity
- Cell cycle
- Prostate cancer
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology