Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways

Su Hwa Kim; Hyun Cheol Bae; Eun Jung Park; Chae Ryun Lee; Byung Joo Kim; Sanghoon Lee; Hyun Ho Park; Sung Joon Kim; Insuk So; Tae Woo Kim; Ju Hong Jeon

doi:10.1016/j.bbrc.2011.02.124

Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways

Su Hwa Kim, Hyun Cheol Bae, Eun Jung Park, Chae Ryun Lee, Byung Joo Kim, Sanghoon Lee, Hyun Ho Park, Sung Joon Kim, Insuk So, Tae Woo Kim^*, Ju Hong Jeon

^*Corresponding author for this work

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

96 Citations (Scopus)

Abstract

The progression of prostate cancer is associated with escape from cell cycle arrest and apoptosis under androgen-depleted conditions. Here, we found that geraniol, a naturally occurring monoterpene, induces cell cycle arrest and apoptosis in cultured cells and tumor grafted mice using PC-3 prostate cancer cells. Geraniol modulated the expression of various cell cycle regulators and Bcl-2 family proteins in PC-3 cells in vitro and in vivo. Furthermore, we showed that the combination of sub-optimal doses of geraniol and docetaxel noticeably suppresses prostate cancer growth in cultured cells and tumor xenograft mice. Therefore, our findings provide insight into unraveling the mechanisms underlying escape from cell cycle arrest and apoptosis and developing therapeutic strategies against prostate cancer.

Original language	English
Pages (from-to)	129-134
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	407
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2011.02.124
Publication status	Published - 2011 Apr 1

Bibliographical note

Funding Information:
Human TRPA8 construct was kindly provided by Dr. Barbara A. Niemeyer (University of Saarland). This study was supported by a grant of the Korea Health 21R&D project, Ministry of Health, Welfare and Family Affairs, Republic of Korea ( A090388 ).

Keywords

Anticancer activity
Apoptosis
Cell cycle
Chemosensitivity
Geraniol
Prostate cancer

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2011.02.124

Cite this

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title = "Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways",

abstract = "The progression of prostate cancer is associated with escape from cell cycle arrest and apoptosis under androgen-depleted conditions. Here, we found that geraniol, a naturally occurring monoterpene, induces cell cycle arrest and apoptosis in cultured cells and tumor grafted mice using PC-3 prostate cancer cells. Geraniol modulated the expression of various cell cycle regulators and Bcl-2 family proteins in PC-3 cells in vitro and in vivo. Furthermore, we showed that the combination of sub-optimal doses of geraniol and docetaxel noticeably suppresses prostate cancer growth in cultured cells and tumor xenograft mice. Therefore, our findings provide insight into unraveling the mechanisms underlying escape from cell cycle arrest and apoptosis and developing therapeutic strategies against prostate cancer.",

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author = "Kim, \{Su Hwa\} and Bae, \{Hyun Cheol\} and Park, \{Eun Jung\} and Lee, \{Chae Ryun\} and Kim, \{Byung Joo\} and Sanghoon Lee and Park, \{Hyun Ho\} and Kim, \{Sung Joon\} and Insuk So and Kim, \{Tae Woo\} and Jeon, \{Ju Hong\}",

note = "Funding Information: Human TRPA8 construct was kindly provided by Dr. Barbara A. Niemeyer (University of Saarland). This study was supported by a grant of the Korea Health 21R\&D project, Ministry of Health, Welfare and Family Affairs, Republic of Korea ( A090388 ). ",

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AU - Kim, Su Hwa

AU - Bae, Hyun Cheol

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AU - Kim, Byung Joo

AU - Lee, Sanghoon

AU - Park, Hyun Ho

AU - Kim, Sung Joon

AU - So, Insuk

AU - Kim, Tae Woo

AU - Jeon, Ju Hong

N1 - Funding Information: Human TRPA8 construct was kindly provided by Dr. Barbara A. Niemeyer (University of Saarland). This study was supported by a grant of the Korea Health 21R&D project, Ministry of Health, Welfare and Family Affairs, Republic of Korea ( A090388 ).

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N2 - The progression of prostate cancer is associated with escape from cell cycle arrest and apoptosis under androgen-depleted conditions. Here, we found that geraniol, a naturally occurring monoterpene, induces cell cycle arrest and apoptosis in cultured cells and tumor grafted mice using PC-3 prostate cancer cells. Geraniol modulated the expression of various cell cycle regulators and Bcl-2 family proteins in PC-3 cells in vitro and in vivo. Furthermore, we showed that the combination of sub-optimal doses of geraniol and docetaxel noticeably suppresses prostate cancer growth in cultured cells and tumor xenograft mice. Therefore, our findings provide insight into unraveling the mechanisms underlying escape from cell cycle arrest and apoptosis and developing therapeutic strategies against prostate cancer.

AB - The progression of prostate cancer is associated with escape from cell cycle arrest and apoptosis under androgen-depleted conditions. Here, we found that geraniol, a naturally occurring monoterpene, induces cell cycle arrest and apoptosis in cultured cells and tumor grafted mice using PC-3 prostate cancer cells. Geraniol modulated the expression of various cell cycle regulators and Bcl-2 family proteins in PC-3 cells in vitro and in vivo. Furthermore, we showed that the combination of sub-optimal doses of geraniol and docetaxel noticeably suppresses prostate cancer growth in cultured cells and tumor xenograft mice. Therefore, our findings provide insight into unraveling the mechanisms underlying escape from cell cycle arrest and apoptosis and developing therapeutic strategies against prostate cancer.

KW - Anticancer activity

KW - Apoptosis

KW - Cell cycle

KW - Chemosensitivity

KW - Geraniol

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ER -

Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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