Abstract
The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC50 values ranging 1.48 to 16.66 μM.
Original language | English |
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Pages (from-to) | 384-387 |
Number of pages | 4 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 63 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2015 May 1 |
Keywords
- Geranylated flavanone
- Nitric oxide inhibitor
- Paulownia coreana
- Paulowniaceae
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery