Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production

Qinghao Jin; Chul Lee; Jin Woo Lee; Dongho Lee; Youngsoo Kim; Jin Tae Hong; Jin Sook Kim; Joo Hwan Kim; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1248/cpb.c14-00839

Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production

Qinghao Jin, Chul Lee, Jin Woo Lee, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Jin Sook Kim, Joo Hwan Kim, Mi Kyeong Lee, Bang Yeon Hwang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC₅₀ values ranging 1.48 to 16.66 μM.

Original language	English
Pages (from-to)	384-387
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	63
Issue number	5
DOIs	https://doi.org/10.1248/cpb.c14-00839
Publication status	Published - 2015 May 1

Keywords

Geranylated flavanone
Nitric oxide inhibitor
Paulownia coreana
Paulowniaceae

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.c14-00839

Cite this

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title = "Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production",

abstract = "The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC50 values ranging 1.48 to 16.66 μM.",

keywords = "Geranylated flavanone, Nitric oxide inhibitor, Paulownia coreana, Paulowniaceae",

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doi = "10.1248/cpb.c14-00839",

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T1 - Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production

AU - Jin, Qinghao

AU - Lee, Chul

AU - Lee, Jin Woo

AU - Lee, Dongho

AU - Kim, Youngsoo

AU - Hong, Jin Tae

AU - Kim, Jin Sook

AU - Kim, Joo Hwan

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

PY - 2015/5/1

Y1 - 2015/5/1

N2 - The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC50 values ranging 1.48 to 16.66 μM.

AB - The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC50 values ranging 1.48 to 16.66 μM.

KW - Geranylated flavanone

KW - Nitric oxide inhibitor

KW - Paulownia coreana

KW - Paulowniaceae

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Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production

Abstract

Keywords

ASJC Scopus subject areas

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