Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats

Soojung Oh; Mak Soon Lee; Sunyoon Jung; Seunghae Kim; Hyeyoung Park; Seonyoung Park; Seog Young Kim; Chong Tai Kim; Young Hee Jo; In Hwan Kim; Yangha Kim

doi:10.1016/j.jff.2016.12.023

Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats

Soojung Oh, Mak Soon Lee, Sunyoon Jung, Seunghae Kim, Hyeyoung Park, Seonyoung Park, Seog Young Kim, Chong Tai Kim, Young Hee Jo, In Hwan Kim, Yangha Kim

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Mitochondrial dysfunction and dyslipidemia are associated with obesity-linked metabolic disorders. The aim of this study was to investigate the effects of ginger extract on muscle mitochondrial biogenesis and high-density lipoprotein-cholesterol (HDL-C) metabolism in high-fat diet-fed rats. Supplementation with ginger extract reduced final body weight and epididymal adipose tissue mass without affecting energy intake (p < 0.05). Ginger extract increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as key genes expression related to mitochondrial biogenesis, including peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), nuclear respiratory factor-1 (NRF-1) and transcription factor A (Tfam) in skeletal muscle (p < 0.05). In addition, ginger extract elevated serum HDL-C along with up-regulating ATP-binding cassette transporter A1 (ABCA1), apolipoprotein A-1 (ApoA-1) and lecithin-cholesterol acyltransferase (LCAT) mRNA in liver (p < 0.05). These results suggest that ginger extract may have a beneficial effect against obesity-related metabolic disorders with elevating muscle mitochondrial biogenesis and serum HDL-C level.

Original language	English
Pages (from-to)	193-200
Number of pages	8
Journal	Journal of Functional Foods
Volume	29
DOIs	https://doi.org/10.1016/j.jff.2016.12.023
Publication status	Published - 2017 Feb 1

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIP) (No. 2016R1A2B4011021) and Food High Pressure Technology Development Project, Korea Food Research Institute (No. 202007-03-03-WT011).

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

Ginger
HDL cholesterol
Metabolic disorder
Muscle mitochondrial biogenesis

ASJC Scopus subject areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jff.2016.12.023

Cite this

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title = "Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats",

abstract = "Mitochondrial dysfunction and dyslipidemia are associated with obesity-linked metabolic disorders. The aim of this study was to investigate the effects of ginger extract on muscle mitochondrial biogenesis and high-density lipoprotein-cholesterol (HDL-C) metabolism in high-fat diet-fed rats. Supplementation with ginger extract reduced final body weight and epididymal adipose tissue mass without affecting energy intake (p < 0.05). Ginger extract increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as key genes expression related to mitochondrial biogenesis, including peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), nuclear respiratory factor-1 (NRF-1) and transcription factor A (Tfam) in skeletal muscle (p < 0.05). In addition, ginger extract elevated serum HDL-C along with up-regulating ATP-binding cassette transporter A1 (ABCA1), apolipoprotein A-1 (ApoA-1) and lecithin-cholesterol acyltransferase (LCAT) mRNA in liver (p < 0.05). These results suggest that ginger extract may have a beneficial effect against obesity-related metabolic disorders with elevating muscle mitochondrial biogenesis and serum HDL-C level.",

keywords = "Ginger, HDL cholesterol, Metabolic disorder, Muscle mitochondrial biogenesis",

author = "Soojung Oh and Lee, {Mak Soon} and Sunyoon Jung and Seunghae Kim and Hyeyoung Park and Seonyoung Park and Kim, {Seog Young} and Kim, {Chong Tai} and Jo, {Young Hee} and Kim, {In Hwan} and Yangha Kim",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIP) (No. 2016R1A2B4011021) and Food High Pressure Technology Development Project, Korea Food Research Institute (No. 202007-03-03-WT011). Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

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AU - Oh, Soojung

AU - Lee, Mak Soon

AU - Jung, Sunyoon

AU - Kim, Seunghae

AU - Park, Hyeyoung

AU - Park, Seonyoung

AU - Kim, Seog Young

AU - Kim, Chong Tai

AU - Jo, Young Hee

AU - Kim, In Hwan

AU - Kim, Yangha

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIP) (No. 2016R1A2B4011021) and Food High Pressure Technology Development Project, Korea Food Research Institute (No. 202007-03-03-WT011). Publisher Copyright: © 2016 Elsevier Ltd

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Mitochondrial dysfunction and dyslipidemia are associated with obesity-linked metabolic disorders. The aim of this study was to investigate the effects of ginger extract on muscle mitochondrial biogenesis and high-density lipoprotein-cholesterol (HDL-C) metabolism in high-fat diet-fed rats. Supplementation with ginger extract reduced final body weight and epididymal adipose tissue mass without affecting energy intake (p < 0.05). Ginger extract increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as key genes expression related to mitochondrial biogenesis, including peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), nuclear respiratory factor-1 (NRF-1) and transcription factor A (Tfam) in skeletal muscle (p < 0.05). In addition, ginger extract elevated serum HDL-C along with up-regulating ATP-binding cassette transporter A1 (ABCA1), apolipoprotein A-1 (ApoA-1) and lecithin-cholesterol acyltransferase (LCAT) mRNA in liver (p < 0.05). These results suggest that ginger extract may have a beneficial effect against obesity-related metabolic disorders with elevating muscle mitochondrial biogenesis and serum HDL-C level.

AB - Mitochondrial dysfunction and dyslipidemia are associated with obesity-linked metabolic disorders. The aim of this study was to investigate the effects of ginger extract on muscle mitochondrial biogenesis and high-density lipoprotein-cholesterol (HDL-C) metabolism in high-fat diet-fed rats. Supplementation with ginger extract reduced final body weight and epididymal adipose tissue mass without affecting energy intake (p < 0.05). Ginger extract increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as key genes expression related to mitochondrial biogenesis, including peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), nuclear respiratory factor-1 (NRF-1) and transcription factor A (Tfam) in skeletal muscle (p < 0.05). In addition, ginger extract elevated serum HDL-C along with up-regulating ATP-binding cassette transporter A1 (ABCA1), apolipoprotein A-1 (ApoA-1) and lecithin-cholesterol acyltransferase (LCAT) mRNA in liver (p < 0.05). These results suggest that ginger extract may have a beneficial effect against obesity-related metabolic disorders with elevating muscle mitochondrial biogenesis and serum HDL-C level.

KW - Ginger

KW - HDL cholesterol

KW - Metabolic disorder

KW - Muscle mitochondrial biogenesis

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ER -

Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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