Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats

Soojung Oh, Mak Soon Lee, Sunyoon Jung, Seunghae Kim, Hyeyoung Park, Seonyoung Park, Seog Young Kim, Chong Tai Kim, Young Hee Jo, In Hwan Kim, Yangha Kim

    Research output: Contribution to journalArticlepeer-review

    37 Citations (Scopus)

    Abstract

    Mitochondrial dysfunction and dyslipidemia are associated with obesity-linked metabolic disorders. The aim of this study was to investigate the effects of ginger extract on muscle mitochondrial biogenesis and high-density lipoprotein-cholesterol (HDL-C) metabolism in high-fat diet-fed rats. Supplementation with ginger extract reduced final body weight and epididymal adipose tissue mass without affecting energy intake (p < 0.05). Ginger extract increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as key genes expression related to mitochondrial biogenesis, including peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), nuclear respiratory factor-1 (NRF-1) and transcription factor A (Tfam) in skeletal muscle (p < 0.05). In addition, ginger extract elevated serum HDL-C along with up-regulating ATP-binding cassette transporter A1 (ABCA1), apolipoprotein A-1 (ApoA-1) and lecithin-cholesterol acyltransferase (LCAT) mRNA in liver (p < 0.05). These results suggest that ginger extract may have a beneficial effect against obesity-related metabolic disorders with elevating muscle mitochondrial biogenesis and serum HDL-C level.

    Original languageEnglish
    Pages (from-to)193-200
    Number of pages8
    JournalJournal of Functional Foods
    Volume29
    DOIs
    Publication statusPublished - 2017 Feb 1

    Bibliographical note

    Funding Information:
    This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIP) (No. 2016R1A2B4011021) and Food High Pressure Technology Development Project, Korea Food Research Institute (No. 202007-03-03-WT011).

    Publisher Copyright:
    © 2016 Elsevier Ltd

    Keywords

    • Ginger
    • HDL cholesterol
    • Metabolic disorder
    • Muscle mitochondrial biogenesis

    ASJC Scopus subject areas

    • Food Science
    • Medicine (miscellaneous)
    • Nutrition and Dietetics

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