Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats

Soojung Oh, Mak Soon Lee, Sunyoon Jung, Seunghae Kim, Hyeyoung Park, Seonyoung Park, Seog Young Kim, Chong Tai Kim, Young Hee Jo, In Hwan Kim, Yangha Kim

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Mitochondrial dysfunction and dyslipidemia are associated with obesity-linked metabolic disorders. The aim of this study was to investigate the effects of ginger extract on muscle mitochondrial biogenesis and high-density lipoprotein-cholesterol (HDL-C) metabolism in high-fat diet-fed rats. Supplementation with ginger extract reduced final body weight and epididymal adipose tissue mass without affecting energy intake (p < 0.05). Ginger extract increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as key genes expression related to mitochondrial biogenesis, including peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), nuclear respiratory factor-1 (NRF-1) and transcription factor A (Tfam) in skeletal muscle (p < 0.05). In addition, ginger extract elevated serum HDL-C along with up-regulating ATP-binding cassette transporter A1 (ABCA1), apolipoprotein A-1 (ApoA-1) and lecithin-cholesterol acyltransferase (LCAT) mRNA in liver (p < 0.05). These results suggest that ginger extract may have a beneficial effect against obesity-related metabolic disorders with elevating muscle mitochondrial biogenesis and serum HDL-C level.

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalJournal of Functional Foods
Publication statusPublished - 2017 Feb 1

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIP) (No. 2016R1A2B4011021) and Food High Pressure Technology Development Project, Korea Food Research Institute (No. 202007-03-03-WT011).

Publisher Copyright:
© 2016 Elsevier Ltd


  • Ginger
  • HDL cholesterol
  • Metabolic disorder
  • Muscle mitochondrial biogenesis

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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