Ginsenosides attenuate kainic acid-induced synaptosomal oxidative stress via stimulation of adenosine A2A receptors in rat hippocampus

Eun Joo Shin; Young Ho Koh; A. Young Kim; Seung Yeoul Nah; Ji Hoon Jeong; Jong Seok Chae; Sun Cheol Kim; Tran Phi Hoang Yen; Hyoung Jong Yoon; Won Ki Kim; Kwang Ho Ko; Hyoung Chun Kim

doi:10.1016/j.bbr.2008.08.038

Ginsenosides attenuate kainic acid-induced synaptosomal oxidative stress via stimulation of adenosine A_2A receptors in rat hippocampus

Eun Joo Shin, Young Ho Koh, A. Young Kim, Seung Yeoul Nah, Ji Hoon Jeong, Jong Seok Chae, Sun Cheol Kim, Tran Phi Hoang Yen, Hyoung Jong Yoon, Won Ki Kim, Kwang Ho Ko, Hyoung Chun Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Treatment with ginsenosides attenuated KA-induced seizures and oxidative stress in the synaptosome, and reduced synaptic vesicles at the presynaptic terminals dose-dependently. The adenosine A_2A receptor antagonist 1,3,7-trimethyl-8-(3-chlorostyryl) xanthine reversed the ginsenoside-mediated pharmacological actions. Neither the adenosine A₁ receptor antagonist 8-cyclopentyl-1,3-dimethylxanthine nor the adenosine A_2B receptor antagonist alloxazine affected the ginsenoside-mediated pharmacological actions. Our results suggest that ginsenosides block KA-induced synaptosomal oxidative stress, associated with hippocampal degeneration, through activation of adenosine A_2A receptors.

Original language	English
Pages (from-to)	239-245
Number of pages	7
Journal	Behavioural Brain Research
Volume	197
Issue number	1
DOIs	https://doi.org/10.1016/j.bbr.2008.08.038
Publication status	Published - 2009 Jan 30

Keywords

Adenosine A receptor
Ginsenosides
Hippocampus
Kainate
Oxidative stress
Synaptosome

ASJC Scopus subject areas

Behavioral Neuroscience

Access to Document

10.1016/j.bbr.2008.08.038

Cite this

Shin, E. J., Koh, Y. H., Kim, A. Y., Nah, S. Y., Jeong, J. H., Chae, J. S., Kim, S. C., Yen, T. P. H., Yoon, H. J., Kim, W. K., Ko, K. H., & Kim, H. C. (2009). Ginsenosides attenuate kainic acid-induced synaptosomal oxidative stress via stimulation of adenosine A_2A receptors in rat hippocampus. Behavioural Brain Research, 197(1), 239-245. https://doi.org/10.1016/j.bbr.2008.08.038

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title = "Ginsenosides attenuate kainic acid-induced synaptosomal oxidative stress via stimulation of adenosine A2A receptors in rat hippocampus",

abstract = "Treatment with ginsenosides attenuated KA-induced seizures and oxidative stress in the synaptosome, and reduced synaptic vesicles at the presynaptic terminals dose-dependently. The adenosine A2A receptor antagonist 1,3,7-trimethyl-8-(3-chlorostyryl) xanthine reversed the ginsenoside-mediated pharmacological actions. Neither the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dimethylxanthine nor the adenosine A2B receptor antagonist alloxazine affected the ginsenoside-mediated pharmacological actions. Our results suggest that ginsenosides block KA-induced synaptosomal oxidative stress, associated with hippocampal degeneration, through activation of adenosine A2A receptors.",

keywords = "Adenosine A receptor, Ginsenosides, Hippocampus, Kainate, Oxidative stress, Synaptosome",

author = "Shin, {Eun Joo} and Koh, {Young Ho} and Kim, {A. Young} and Nah, {Seung Yeoul} and Jeong, {Ji Hoon} and Chae, {Jong Seok} and Kim, {Sun Cheol} and Yen, {Tran Phi Hoang} and Yoon, {Hyoung Jong} and Kim, {Won Ki} and Ko, {Kwang Ho} and Kim, {Hyoung Chun}",

note = "Funding Information: This study was supported by a grant (M103KV010013-08K2201-01310) from the Brain Research Center from 21st Century Frontier Research Program funded by the Ministry of Science and Technology, Republic of Korea. JS Chae and SC Kim were supported by BK 21 program. Equipment at the Institute of Pharmaceutical Science in the Kangwon National University was used for this study. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.bbr.2008.08.038",

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AU - Shin, Eun Joo

AU - Koh, Young Ho

AU - Kim, A. Young

AU - Nah, Seung Yeoul

AU - Jeong, Ji Hoon

AU - Chae, Jong Seok

AU - Kim, Sun Cheol

AU - Yen, Tran Phi Hoang

AU - Yoon, Hyoung Jong

AU - Kim, Won Ki

AU - Ko, Kwang Ho

AU - Kim, Hyoung Chun

N1 - Funding Information: This study was supported by a grant (M103KV010013-08K2201-01310) from the Brain Research Center from 21st Century Frontier Research Program funded by the Ministry of Science and Technology, Republic of Korea. JS Chae and SC Kim were supported by BK 21 program. Equipment at the Institute of Pharmaceutical Science in the Kangwon National University was used for this study. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2009/1/30

Y1 - 2009/1/30

N2 - Treatment with ginsenosides attenuated KA-induced seizures and oxidative stress in the synaptosome, and reduced synaptic vesicles at the presynaptic terminals dose-dependently. The adenosine A2A receptor antagonist 1,3,7-trimethyl-8-(3-chlorostyryl) xanthine reversed the ginsenoside-mediated pharmacological actions. Neither the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dimethylxanthine nor the adenosine A2B receptor antagonist alloxazine affected the ginsenoside-mediated pharmacological actions. Our results suggest that ginsenosides block KA-induced synaptosomal oxidative stress, associated with hippocampal degeneration, through activation of adenosine A2A receptors.

AB - Treatment with ginsenosides attenuated KA-induced seizures and oxidative stress in the synaptosome, and reduced synaptic vesicles at the presynaptic terminals dose-dependently. The adenosine A2A receptor antagonist 1,3,7-trimethyl-8-(3-chlorostyryl) xanthine reversed the ginsenoside-mediated pharmacological actions. Neither the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dimethylxanthine nor the adenosine A2B receptor antagonist alloxazine affected the ginsenoside-mediated pharmacological actions. Our results suggest that ginsenosides block KA-induced synaptosomal oxidative stress, associated with hippocampal degeneration, through activation of adenosine A2A receptors.

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KW - Kainate

KW - Oxidative stress

KW - Synaptosome

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