Glycated milk protein fermented with Lactobacillus rhamnosus ameliorates the cognitive health of mice under mild-stress condition

Nam Su Oh, Jae Yeon Joung, Ji Young Lee, Jae Gwang Song, Sangnam Oh, Younghoon Kim, Hyung Wook Kim, Sae Hun Kim

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


This study aimed to investigate the effects of glycated milk casein (Gc) fermented with Lactobacillus rhamnosus 4B15 (FGc) on the intestinal microbiota and physiological and behavioral properties in mice under chronic stress. Mice were administered Gc or FGc for 10 weeks and then exposed to unpredictable chronic mild stress (UCMS) for 7 weeks. FGc administration restored alterations of gut microbiota induced by UCMS. Moreover, FGc significantly reduced the stress-induced increase in serum corticosterone and decrease in serotonin levels. Anxiety-like behaviors induced by UCMS were also significantly decreased in the FGc group. UCMS-induced dysregulation of gene and protein expression related to neuroendocrine function, neuronal development, and inflammation, and gut-blood-brain barrier function was controlled by FGc pre-treatment. These results strongly suggest the protective effects of FGc targeting of intestinal microbiota for abnormal brain activity, which is consistent with the view that FGc plays an important role in regulating stress-related gut-brain axis disorders.

Original languageEnglish
Pages (from-to)1643-1661
Number of pages19
JournalGut Microbes
Issue number6
Publication statusPublished - 2020 Nov 1

Bibliographical note

Funding Information:
This research was supported by the High Value-Added Food Technology Development Program of the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (iPET), and the Ministry for Food, Agriculture, Forestry and Fisheries of Republic of Korea [115006-03-3-SB010, 318090-03-1-SB010] and a grant from the Next-Generation BioGreen 21 Program [PJ01322302], Rural Development Administration, Republic of Korea.

Publisher Copyright:
© 2020, © 2020 Taylor & Francis Group, LLC.


  • Chronic mild stress
  • Lactobacillus rhamnosus 4B15
  • brain-gut-microbiome axis
  • casein
  • glycation

ASJC Scopus subject areas

  • Microbiology (medical)
  • Gastroenterology
  • Infectious Diseases
  • Microbiology


Dive into the research topics of 'Glycated milk protein fermented with Lactobacillus rhamnosus ameliorates the cognitive health of mice under mild-stress condition'. Together they form a unique fingerprint.

Cite this